An unusual co-occurrence of Langerhans cell histiocytosis and Rosai-Dorfman disease: report of a case and review of the literature.

Background: The co-occurrence of Langerhans cell histiocytosis (LCH; disorder characterized by proliferation of Langerhans cells) and Rosai-Dorfman disease (RDD; histiocytic entity that is one of the non-Langerhans cell diseases) is extremely rare and raises several questions regarding the nature of the diseases.

Methods: We describe a 10-year-old boy who presented with a 3-month history of right scalp swelling. Clinical, pathological, and imaging evaluation disclosed multiple LCH of bone and cutaneous RDD.

Infantile haemangiomas and quality of life.

Objective: To determine the quality of life (QOL) and self-esteem of children with infantile haemangiomas using objective measures.

Design: Twenty-one children, 5-8 years old, with a diagnosis of head or neck haemangioma measuring 2 cm or more, were compared with 22 children with no history of haemangioma.

Setting: A tertiary medical centre in the north of Israel.

Participation in leisure activities and sensory modulation deficiencies of children with atopic dermatitis.

Aim: To examine whether the complexity of atopic dermatitis (AD) symptoms and the sensory modulation deficiencies (SMD) that accompany it may limit child's preference to participate in leisure activities.

Methods: Thirty-seven children diagnosed with AD and 104 healthy peers aged 6-11 years participated in this study. Disease severity was assessed using SCORAD scores.

The relationship between sensory hypersensitivity and sleep quality of children with atopic dermatitis.

This study aims to investigate the impact of sensory hypersensitivity in children with atopic dermatitis (AD) and to evaluate a possible relationship between sensory hypersensitivity, sleep quality and disease severity in AD. Fifty-seven AD patients and 37 healthy children, aged 3-10 years, participated in this study. Disease severity was assessed using the Severity Scoring of Atopic Dermatitis (SCORAD) Score.

Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis.

Single-gene disorders offer unique opportunities to shed light upon fundamental physiological processes in humans. We investigated an autosomal-recessive phenotype characterized by alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome). By using homozygosity mapping and candidate-gene analysis, we identified a loss-of-function mutation in RBM28, encoding a nucleolar protein.

[Acne--merely a cosmetic problem? Acne associated musculoskeletal syndromes].

Acne can be associated with severe musculoskeletal and constitutional symptoms. This is a case history of a 15 year-old boy with severe acne, treated with isotretinoin, who was admitted because of high fever and weight loss of 3 weeks duration. His complaints were of severe chest and back pain, and inability to walk.

The sensory profile of children with atopic dermatitis as determined by the sensory profile questionnaire.

Background: The increasing prevalence of atopic dermatitis (AD) combined with the limited efficacy of current therapies emphasizes the need to improve care quality for patients with AD. This study aims to characterize the sensory profile of children with AD as expressed in daily living.

Methods: In all, 53 patients with AD and 61 healthy children, aged 3 to 10 years, participated in this study.

Nontuberculous mycobacterial infections of the skin: A retrospective study of 25 cases.

Background: Absence of a pathognomonic clinical picture and variable histologic findings often delay diagnosis of nontuberculous mycobacteria (NTM)-induced cutaneous infections, and antimicrobial therapy varies.

Objective: We sought to investigate the clinical, microbiologic, and pathological findings of cutaneous NTM infections and response to different treatments.

Methods: Records of patients with NTM infections of the skin confirmed by positive cultures or histologic findings were reviewed.

Sister Mary Joseph's nodule as a presenting sign of internal malignancy.

CASE 1: A 64-year-old, otherwise healthy woman was referred to the surgery clinic for a presumed umbilical hernia. On physical examination, a cutaneous nodule was noted on the umbilical region and the patient was referred to the dermatology clinic. The patient was reexamined and an erythematous nodule was observed in the umbilicus measuring 2.

Leishmania tropica in northern Israel: a clinical overview of an emerging focus.

Background: In Israel, most cutaneous leishmaniasis (CL) is caused by Leishmania major. Recently a new focus of CL caused by Leishmania tropica has been described in Tiberias and the surrounding area of northern Israel.

Objective: The aim of this study was to evaluate clinical (size, number, location, and type of lesion) and laboratory (culture and polymerase chain reaction [PCR] analysis) parameters at diagnosis, response to treatment, and outcome of patients with CL due to L tropica.

Subcutaneous panniculitic T-cell lymphoma in children: response to combination therapy with cyclosporine and chemotherapy.

We describe 2 adolescent boys with facial swelling and/or subcutaneous nodules and fever. Extensive evaluation, including several biopsy specimens, led to a diagnosis of subcutaneous panniculitic T-cell lymphoma, an entity rarely seen in children. Both patients were treated with oral cyclosporine in an effort to suppress the cytokine release from T-cells that has been thought to induce the hemophagocytic syndrome.

A child with both Langerhans and non-Langerhans cell histiocytosis.

The histiocytic syndromes consist of a group of disorders that share in common the proliferation of cells of the monocytic/macrophage lineage. It has been conventional to divide the histiocytoses into two separate groups: Langerhans cell histiocytosis (LCH) and non-LCH. We present a 2-year-old Hispanic boy who was referred to the dermatology clinic for evaluation of an asymptomatic cutaneous eruption of the head and upper trunk.