Shifting the balance: soluble ADAM10 as a potential treatment for Alzheimer's disease.

Introduction: Accumulation of amyloid β in the brain is regarded as a key initiator of Alzheimer's disease pathology. Processing of the amyloid precursor protein (APP) in the amyloidogenic pathway yields neurotoxic amyloid β species. In the non-amyloidogenic pathway, APP is processed by membrane-bound ADAM10, the main α-secretase in the nervous system.

Sub-inhibitory membrane damage undermines Staphylococcus aureus virulence.

We investigated antibacterial properties of a recently described membrane-active lipopeptide, COOcO (decanoyl-ornithyl-ornithyl-dodecanoyl-ornithyl-amide) against Gram-positive bacteria (GPB). Minimal inhibitory concentrations (MICs) and kinetics were compared in culture media and plasma. Chemo-sensitization to antibiotics was determined using the checkerboard assay.