Publications by authors named "Aydar Abubakirov"
Article Synopsis
- - GnRHa triggering during fresh embryo transfers can lead to worse clinical outcomes due to luteal phase insufficiency, so this study analyzed 153 patients to compare different triggering methods and their hormonal impacts.
- - Group I received GnRHa + hCG support, Group II had a dual trigger (GnRHa + hCG), and Group III (control) was given 10,000 IU hCG; progesterone levels were notably lower in Groups I and II compared to Group III, but no significant differences in pregnancy outcomes were observed.
- - Pregnant women exhibited higher estradiol and progesterone levels on the day of the pregnancy test, while moderate ovarian hyperstimulation syndrome (OHSS) cases were noted in
Article Synopsis
- The study investigates the possibility of maturing oocytes from oophorectomy samples in patients with malignant ovarian tumors as a way to preserve fertility, especially in the context of oncofertility.
- A total of 27 patients were included, revealing that 99 cumulus-oocyte complexes were collected from 17 patients and resulted in a maturation rate of about 40%, with some oocytes being successfully vitrified for future use.
- It is concluded that this method may be beneficial for younger patients with specific health conditions before undergoing surgery or chemotherapy, highlighting the importance of AMH levels and tumor burden in the decision-making process.
Improved maturation competence of ovarian tissue oocytes using a biphasic in vitro maturation system for patients with gynecological malignancy: a study on sibling oocytes.
J Assist Reprod Genet
June 2021
Purpose: To investigate the developmental competence of ovarian tissue oocytes from patients with gynecological tumors using a biphasic in vitro maturation system with capacitation (CAPA-IVM) in comparison with standard IVM.
Methods: This sibling pilot study included 210 oocytes in 10 patients with gynecological malignancies. After ovariectomies, ovaries were cut into even halves and immature cumulus-oocyte complexes (COCs) were retrieved from the ovarian tissue.
Problem: Interleukin 8 (IL-8), vascular endothelial growth factor A (VEGFA), its receptors 1 (VEGFR1) and 2 (VEGFR2) are associated with ovarian hyperstimulation syndrome (OHSS) pathophysiological mechanisms. The aim of this study was to evaluate the concentrations of these cytokines depending on the way of ovulation triggering.
Method Of Study: A total of 51 high-responder patients underwent IVF program and received gonadotropin-releasing hormone agonists (GnRHa) trigger + 1500 IU human chorionic gonadotropin (hCG) support on the oocyte pick-up (OPU) day (group I), dual trigger (GnRHa + 1500 IU hCG; group II), or hCG trigger 10,000 IU (group III) for the final oocyte maturation.
Article Synopsis
- The field of 3D bioprinting, which involves creating human tissues and organs using advanced technology, raises various bioethical and legal concerns that are still largely underexplored globally, even in Russia.!* -
- The complexity of 3D bioprinting extends beyond just the technical aspects, intertwining with broader discussions in modern science, technology, bioethics, and philosophy.!* -
- This article specifically focuses on the ethical and legal implications related to the bioprinting of artificial human organs, highlighting the need for more thorough dialogue in these areas.!*
Research Question: Does double stimulation (DuoStim) affect cumulus cell gene expression in luteal-phase-derived oocytes?
Design: This prospective observational study included 39 patients with reduced ovarian reserve. Fifteen patients (group 1) underwent IVF with a gonadotrophin-releasing hormone antagonist in the follicular phase and 24 patients (group 2) underwent DuoStim. A total of 149 cumulus cell samples were divided into two groups according to the phase of the cycle: group 1 included 55 follicular-phase-derived oocytes and group 2 included 94 luteal-phase-derived oocytes.
With the increased rate of stable remission after gonadotoxic cancer treatment, new methods of fertility preservation are required in order to provide the best possible care for oncological patients. Here, we report an original case of euploid blastocyst cryopreservation after in vitro maturation of ovarian tissue oocytes (OTO IVM). Thirty-three oocytes were obtained from the ovarian tissue after ovariectomy in the breast cancer patient.
View Article and Find Full Text PDFShould we transfer poor quality embryos?
Fertil Res Pract
February 2020
Background: To evaluate if it is safe and effective to transfer poor quality embryos.
Methods: It was a retrospective analysis using individual patient data with positive controls. All patients undergoing embryo transfers of poor quality embryos on day 3 or on day 5 as part of fresh In Vitro Fertilization (IVF) cycles performed between 2012 and 2016.