Publications by authors named "Aydan Kılıcarslan"
The relationship between clinical prognostic factors, microvascular density, and tumor-infiltrating lymphocytes with CD47 and SIRPα expression in diffuse large B cell lymphomas.
Leuk Res
December 2024
CD47 interacts with signal regulatory protein alpha (SIRPα) on macrophages to deliver an anti-phagocytic signal, enabling tumor cells to evade immune destruction. This study explores the relationship between CD47 and SIRPα expression and key clinical prognostic factors, microvascular density (MVD), and tumor-infiltrating lymphocytes (TIL) in Diffuse Large B Cell Lymphoma (DLBCL) cases. We analyzed tissue samples from 122 DLBCL cases using tissue microarray (TMA) blocks and immunohistochemical staining for CD47, SIRPα, CD31, and CD3.
View Article and Find Full Text PDFMalignant mesenchymal thyroid tumors are one of the rarest types of thyroid cancer. Clinically, these tumors present as a rapidly growing thyroid mass. Due to their rarity and nonspecific findings, they are not the first conditions that come to mind during differential diagnosis.
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- Lymph node metastasis (LNM) is crucial for determining the prognosis in differentiated thyroid cancer (DTC), and the study focuses on how certain clinical and pathological factors influence LNM in patients.
- Among 150 patients analyzed after thyroid surgery, the majority had papillary thyroid carcinoma, with key findings indicating that larger tumors (greater than 11.5 mm) and extrathyroidal extension (ETE) were strongly associated with a higher likelihood of LNM.
- The study concludes that features like ETE, lymphovascular invasion (LVI), positive surgical margins, and tumor size are significant indicators of LNM, highlighting the need for careful monitoring of patients who may have undetected metastases before surgery.
Purpose: To determine whether early repeat fine needle aspiration biopsy (FNA) has an effect on adequate or atypia of undetermined significance (AUS) cytology rates in thyroid nodules with inadequate or AUS result in the first FNA.
Methods: Nodules of patients who underwent repeat biopsy due to insufficient or AUS cytology between 2019-2022 were included. Data of the patients and ultrasonographic, cytological and histopathological results of the nodules were recorded.
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- The study aimed to assess the effectiveness of Frozen Section (FS) analysis during the reimplantation phase of knee surgeries in patients with unclear inflammation but no infection signs.
- 66 out of 78 patients showed no complications after surgery, but complications occurred in 12 patients, leading to some requiring more serious interventions like amputations.
- The findings indicated that both intraoperative (iFS) and review (rFS) FS analyses had low sensitivity and specificity for detecting infections, highlighting the need for careful monitoring of clinical symptoms instead of solely relying on FS results.
Aim: We aimed to evaluate the effectiveness of optical coherence tomography (OCT) in the differential diagnosis of anterior segment diseases such as ocular surface squamous neoplasia (OSSN) and pterygium.
Methods: Patients who were pre-diagnosed with either OSSN (21) or pterygium (19) between January 2020 and November 2022 were included in this retrospective study. Anterior segment photographs and anterior segment optical coherence tomography (AS-OCT) measurements were obtained from each patient.
Objective: We aimed to evaluate the patients diagnosed with papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) in terms of clinical, ultrasonographical (US) and histopathological features and their relationships with tumor size.
Methods: We retrospectively evaluated 881 patients who underwent thyroid surgery in our clinic and diagnosed with PTC histopathologically were enrolled the study. Demographic characteristics, US findings and histopathological features were evaluated.
: To investigate the impact of long-term scleral contact lens (ScCL) wear on corneal curvature, corneal thickness, tear film function, and ocular surface in patients with keratoconus.: Sixteen keratoconus patients wearing ScCLs for 6 months were enrolled in the study. Corneal topography, tear osmolarity test, Schirmer 1 test, tear film break-up time (TBUT) test, and impression cytology analysis were assessed at baseline and follow-up examinations.
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- The study aimed to assess the effects of irisin in a mouse model experiencing hind limb ischemia reperfusion (I/R).
- Mice were divided into four groups to analyze the impacts of irisin administration before the I/R procedure, focusing on biochemical and histopathological changes after 2 hours of ischemia and 2.5 hours of reperfusion.
- Results indicated that irisin could enhance total antioxidant status and reduce inflammation, suggesting protective benefits against skeletal muscle damage due to ischemia reperfusion injury.
Background: The programmed death receptor (PD-1) and ligand (PD-L1) pathway act by suppressing the antitumor response in chronic Hodgkin lymphoma (cHL). In this study, we aimed to investigate the effect of PD-1, PD-L1, and Epstein-Barr virus (EBV) positivity on prognosis at the initial diagnosis of cHL.
Material And Methods: Thirty-six patients with cHL were retrospectively analyzed.
Purpose: To investigate the long-term effects that CXL has on the tear function and ocular surface in keratoconus.
Methods: Twenty-one consecutive patients (24 eyes) with progressive keratoconus scheduled for CXL were included. All patients underwent the following procedures: conjunctival impression cytology analysis, ocular surface disease index (OSDI) score, tear osmolarity test, Schirmer test, tear film breakup time (TBUT), ophthalmic surface fluorescein (Fl) staining, and topographical corneal evaluation before as well as 3 and 18 months after accelerated CXL.
Background: We aimed to compare the cytology and histopathology results of hot, cold, and warm nodules in patients who had thyroidectomy due to toxic multinodular goiter (TMNG).
Methods: Five hundred and nine thyroid nodules from 413 patients who had operation with TMNG were included in this retrospective study. The nodules were categorized as hot, cold, and warm groups.
Article Synopsis
- * Rats were divided into three groups: a control group, a group receiving iron dextran, and a group receiving both iron dextran and exenatide.
- * Results showed that exenatide significantly reduced markers of oxidative stress and apoptosis in the testicular cells of the iron-overloaded rats, suggesting it may protect against damage from iron accumulation.
Introduction: The incidence of thyroid cancer is increasing which can be attributed in part to improved ultrasonography (US) methods and increased detection of incidental thyroid carcinomas (ITC). We aimed to compare ITC with nonincidental thyroid carcinomas (NITC) in this study.
Methods: Retrospective analyses of 906 individual patients who were operated for benign and malignant thyroid disease and had a final histopathological diagnosis of thyroid carcinoma were enrolled in this study.
Article Synopsis
- The Her2/neu signaling pathway is crucial in various solid tumors, but its role in colorectal carcinoma (CRC) is not well-understood.
- This study investigated the relationship between Her2/neu overexpression and clinical features in CRC by examining tumor samples from 100 resections with immunohistochemical staining and silver in-situ hybridization.
- Results showed that Her2/neu overexpression occurred in 12 cases with amplification found in 10, but no significant connection was identified between Her2/neu status and clinicopathological parameters or overall survival, suggesting the need for more comprehensive studies.
Article Synopsis
- This study investigated the impact of hydroxyethyl starch (Voluven) on kidney tissue in rats suffering from late renal failure caused by ureteral obstruction.
- Rats were divided into four groups for experimentation: control, HES treatment, unilateral ureteral obstruction, and unilateral ureteral obstruction with HES treatment.
- Results showed that ureteral obstruction increased urea and creatinine levels, and administering HES exacerbated these levels along with boosting other harmful parameters, indicating a need for caution when using HES in renal failure cases.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy. Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in the majority of ccRCC. Targeting immune checkpoints with the blockade of PD-1 and its ligand PD-L1 reorganizes T-cell activity in tumor microenvironment and provides important antitumor responses.
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- - Chemotherapy has limited effectiveness for advanced endometrial cancers (ECs), prompting research into immune evasion mechanisms and potential treatments involving immune modulators like PD-1, PD-L1, and PD-L2, which have been studied more in other cancer types.
- - A retrospective study of 127 EC patients investigated the expression of PD-1, PD-L1, and PD-L2 using immunohistochemical analysis, revealing positive staining in tumor and immune cells, with no PD-1 detected in tumor cells.
- - The study found a significant correlation between tumor stages and PD-L1 expression, with more PD-L1 negative tumors in early-stage EC, suggesting that targeting PD-1, PD-L1,
Objective: Although classical Hodgkin lymphoma (cHL) has a relatively good prognosis, it also entails different treatment responses and involves patients who have different clinical courses. Our aim was to investigate c-Myc, Bcl-2 and EBV biomarkers in cHL and their relationship with the IPS score.
Material And Method: c-Myc and Bcl-2 immunohistochemical staining with EBER in situ hybridization (EBER-ISH) was applied to the paraffin sections of 94 cases diagnosed as cHL.
Article Synopsis
- This study aimed to compare the expression of p53 and Ki67 in basal cell carcinoma (BCC) cases located in unusual versus usual sites, given their roles in cell growth in skin cancers.
- Researchers examined 33 tissue samples, finding that tumors in unusual locations were larger, and size increased with patient age; however, there were no significant differences in p53 and Ki67 expression between the groups.
- A correlation was observed between the staining rates of Ki67 and p53, but overall, the findings indicate no notable differences in expression levels for these markers across the locations studied.
Article Synopsis
- The study focuses on the challenges of accurately diagnosing parathyroid carcinoma due to uncertain histopathological findings and the potential role of immunohistochemical markers.
- Researchers reevaluated cases of atypical parathyroid adenoma and parathyroid carcinoma from 2010 to 2015, applying various immunohistochemical markers to help in diagnosis.
- Results indicated that the global loss of calcium-sensing receptor (CaSR) staining is a significant negative marker for carcinoma, supporting its use in identifying increased malignancy in difficult cases.
Background/aim: To evaluate the malignancy risk of thyroid nodules in different clinical thyroid diseases. Materials and methods: Patients who underwent thyroidectomy between 2007 and 2014 were grouped as euthyroid, hypothyroid, and hyperthyroid. Further classification was made depending on the presence of solitary/multiple thyroid nodules.
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