This in vitro study aimed to evaluate the effect of two different polymer-based CAD/CAM materials; resin-nano ceramic (Lava Ultimate [LVU]) and composite (CERASMART [CS]), their different surface pre-treatments, and use of different resin cements on the µTBS of adhesively bonded CAD/CAM onlays to dentin. CAD/CAM materials were cut into slabs and divided into five groups according to the surface pre-treatments applied: Silane Primer, OptiBond XTR adhesive, Silane Primer+OptiBond XTR adhesive, Single Bond Universal (SBU), and RelyX Ceramic Primer+SBU. The LVU and CS specimens were bonded to the mid-coronal dentin of 50 non-carious human molars using NX3 resin cement with OptiBond XTR or RelyX Ultimate with SBU.
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