Distinct pathway activities are associated with prognosis and response to bortezomib-containing treatment in MCL1-M based molecular subtypes of multiple myeloma.

Multiple myeloma (MM) is the second most prevalent hematological malignancy and remains incurable with remarkable heterogeneity in prognosis and treatment response across the patients. Clinical diagnosis and the existing molecular classification systems are inadequate for predicting treatment responses. Based on the convergence between plasma cell development and MM pathogenesis, we identified a gene co-expression module centered on the plasma cell survival regulator MCL1 (MCL1 module, MCL1-M) in the transcriptomes of pre-treated MM, which enabled stratification of MM patients into MCL1-M high and MCL1-M low molecular subtypes with subtype-specific prognosis and response to bortezomib-containing treatment.

Factors And Determinants Associated With Prevalence Of Anaemia In Adults In Karachi, Pakistan.

Objectives: To assess the demographic and dietary factors associated with the prevalence of anaemia in multi-ethnic urban settings.

Methods: The cross-sectional community-based survey study was conducted from August 2020 to May 2021 in Karachi East district, and comprised healthy adults of either gender aged 20-60 years. Data was collected using a pretested questionnaire.

Prevalence and sociodemographic factors associated with stunting and thinness in adolescent females: A cross sectional study from Pakistan.

Objective: To explore the prevalence and socio-demographic factors associated with stunting and thinness in adolescent females.

Methods: The survey-based cross-sectional study was conducted in randomly selected schools of the Kotri Taulka of Jamshoro District in Sindh, Pakistan, from October to December 2019, and comprised healthy female adolescents aged 10-19 years. Data about demographic and anthropometric factors was collected using a pre-tested questionnaire.

Demographic factors associated with acceptance, hesitancy, and refusal of COVID-19 vaccine among residents of Sukkur during lockdown: A cross sectional study from Pakistan.

Background: The World Health Organization has identified vaccine hesitancy among one of the top 10 threats to global health. The ongoing COVID-19 pandemic has devastated global health with higher morbidities and mortality rates. Reducing vaccine hesitancy could achieve immunization.

Prevalence and Risk Factors Associated with Hepatitis B and C in Nawabshah, Sindh, Pakistan.

In Pakistan, viral hepatitis is a serious public health problem affecting millions of people. Both hepatitis B and hepatitis C infections are spreading rapidly in all provinces of Pakistan, including Sindh, because of lack of knowledge about routes of transmission, low literacy rate, reuse of syringes, piercing, and other factors. However, information about the prevalence and risk factors is inadequate.

Elevated signature of a gene module coexpressed with CDC20 marks genomic instability in glioma.

Genomic instability (GI) drives tumor heterogeneity and promotes tumor progression and therapy resistance. However, causative factors underlying GI and means for clinical detection of GI in glioma are inadequately identified. We describe here that elevated expression of a gene module coexpressed with CDC20 (CDC20-M), the activator of the anaphase-promoting complex in the cell cycle, marks GI in glioma.

MCL1 gene co-expression module stratifies multiple myeloma and predicts response to proteasome inhibitor-based therapy.

Multiple myeloma (MM) is the second most common hematologic cancer, characterized by abnormal accumulation of plasma cells in the bone marrow. The extensive biological and clinical heterogeneity of MM hinders effective treatment and etiology research. Several molecular classification systems of prognostic impact have been proposed, but they do not predict the response to treatment nor do they correlate to plasma cell development pathways.