Publications by authors named "Ayauly Duisenbek"
Article Synopsis
- This study analyzed new circulating markers related to macrovascular complications (MVC) in patients with type 2 diabetes mellitus (T2DM) by comparing controls, patients with T2DM, and those with T2DM and vascular complications.
- Results showed significant differences in the expression of specific microRNAs (miRs) between groups, particularly in miR-126a-3p, which was decreased in patients with vascular complications.
- The study identified predictive models using various biomarkers, including HbA1c, creatinine, total cholesterol, and specific miRs, suggesting new avenues for understanding and predicting MVC in individuals with T2DM.
A common denominator of metabolic diseases, including type 2 diabetes Mellitus, dyslipidemia, and atherosclerosis, are elevated oxidative stress and chronic inflammation. These complex, multi-factorial diseases are caused by the detrimental interaction between the individual genetic background and multiple environmental stimuli. The cells, including the endothelial ones, acquire a preactivated phenotype and metabolic memory, exhibiting increased oxidative stress, inflammatory gene expression, endothelial vascular activation, and prothrombotic events, leading to vascular complications.
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