Publications by authors named "Ayari Ike"
Pharmaceutics
February 2022
Article Synopsis
- The study improved the bioavailability of irbesartan (IRB) by creating a nanocrystalline tablet (IRB-NP tablet) from its suspensions, addressing previous stability issues.
- The IRB-NP tablet was developed using various additives and showed a smaller particle size (approximately 118 nm) upon redispersion, leading to enhanced solubility and absorption compared to the traditional microcrystalline tablet (IRB-MP tablet).
- Additionally, the IRB-NP tablet demonstrated a greater ability to reduce blood pressure in stroke-prone hypertensive rats than the IRB-MP tablet, highlighting its potential therapeutic advantages.
