Publications by authors named "Ayano Sunohara"
Unlike adult mammalian wounds, early embryonic mouse skin wounds completely regenerate and heal without scars. Analysis of the underlying molecular mechanism will provide insights into scarless wound healing. Twist2 is an important regulator of hair follicle formation and biological patterning; however, it is unclear whether it plays a role in skin or skin appendage regeneration.
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- Mice embryos have a unique ability to heal wounds without scars up to embryonic day 13 (E13), but this ability decreases after E17, leading to scar formation.
- The protein Lhx2 plays a crucial role in managing hair follicle stem cells during this healing process, with its expression increasing after E13.
- When Lhx2 was knocked down in embryos at E15, wound healing was significantly delayed and scars became more prominent, indicating its importance in both cell division related to healing and the development of scars.
Wnt proteins secrete glycoproteins that are involved in various cellular processes to maintain homeostasis during development and adulthood. However, the expression and role of Wnt in wound healing have not been fully documented. Our previous studies have shown that, in an early-stage mouse fetus, no scarring occurred after cutaneous wounding, and complete regeneration was achieved.
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