Publications by authors named "Ayano Katsura"
Background: Hyposalivation is treated using oral cholinergic drugs; however, systemic side effects occasionally lead to discontinuation of treatment. We aimed to investigate the effects of transdermal pilocarpine on the salivary gland skin on saliva secretion and safety in rats.
Methods: Pilocarpine was administered to rats orally (0.
Article Synopsis
- Transdermal scopolamine applied to the area behind the ear is effective in reducing drooling in rats, with different application sites influencing its effectiveness.
- The study found that applying scopolamine ointment directly over the salivary glands resulted in a more significant reduction in saliva volume compared to applying it on the back.
- Higher concentrations of scopolamine were detected in the salivary glands when the ointment was applied over them, indicating that this method may be an efficient treatment option for drooling.
Previous studies postulated that chronic administration of varenicline, a partial and full agonist at α4β2 and α7 nicotinic acetylcholine receptors (nAChRs), respectively, enhances recognition memory. However, whether its acute administration is effective, on which brain region(s) it acts, and in what signaling it is involved, remain unknown. To address these issues, we conducted a novel object recognition test using male C57BL/6J mice, focusing on the medial prefrontal cortex (mPFC), a brain region associated with nicotine-induced enhancement of recognition memory.
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