An inverse relationship exists between rheumatoid arthritis severity and β-cryptoxanthin intake, indicating potential protective effects.
Oral administration of β-cryptoxanthin to arthritic rats reduced cartilage degradation by inhibiting enzymes that break down a key cartilage protein, aggrecan.
In cell cultures, β-cryptoxanthin not only decreased harmful gene expression related to cartilage breakdown but also promoted the production of cartilage building blocks, suggesting it may help manage arthritis progression.