Publications by authors named "Ayana Mori"
The demand for the essential commodity chemical 1,2-propanediol (1,2-PDO) is on the rise, as its microbial production has emerged as a promising method for a sustainable chemical supply. However, the reliance of 1,2-PDO production in Escherichia coli on anaerobic conditions, as enhancing cell growth to augment precursor availability remains a substantial challenge. This study presents glucose-based aerobic production of 1,2-PDO, with xylose utilization facilitating cell growth.
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- Short-chain esters like isobutyl and isoamyl acetate are valuable in industries such as flavors, fragrances, solvents, and biofuels.
- The research focused on using the yeast Yarrowia lipolytica to biosynthesize these esters by introducing specific alcohols and enhancing the production with genetic modifications of the yeast.
- By optimizing conditions and increasing acetyl-CoA levels, the study achieved significant yields of isoamyl acetate, showcasing the potential of Y. lipolytica in the effective production of various acetate esters.
Disease pathogenesis and barrier functions regulated by group 3 innate lymphoid cells.
Semin Immunopathol
January 2024
The mucosal surface is in constant contact with foreign antigens and is regulated by unique mechanisms that are different from immune responses in the peripheral organs. For the last several decades, only adaptive immune cells such as helper T (Th) cells, Th1, Th2, or Th17 were targeted to study a wide variety of immune responses in the mucosal tissues. However, since their discovery, innate lymphoid cells (ILCs) have been attracting attention as a unique subset of immune cells that provide border defense with various functions and tissue specificity.
View Article and Find Full Text PDFp-Nitrobenzoate production from glucose by utilizing p-aminobenzoate N-oxygenase: AurF.
Enzyme Microb Technol
December 2023
Article Synopsis
- Nitroaromatic compounds are useful in industry but their production is often dangerous and not very efficient.
- Researchers developed a genetically modified E. coli strain called PN-1 that successfully produces p-nitrobenzoate (PNBA) from glucose by disrupting genes involved in PNBA degradation and expressing a specific enzyme.
- Further enhancements led to a new strain, PN-4Ap, which produced higher amounts of PNBA (975 mg/L) by disrupting genes that compete for resources, showcasing the ability of microbes for sustainable nitroaromatic compound production.