Publications by authors named "Ayami Kato"
Background: High plasma levels of Lp(a) are associated with a worse prognosis in patients with coronary artery disease. The aim of the present study is to clarify the association between high lipoprotein a [Lp(a)] levels and vulnerable characteristics of nonculprit plaques in patients with acute coronary syndrome (ACS).
Methods: A total of 185 consecutive patients with ACS who underwent optical coherence tomography imaging of nonculprit plaques in the culprit vessels were enrolled.
Background: Reducing low-density lipoprotein cholesterol (LDL-C) levels with statins slows the progression of atherosclerotic plaques and reduces cardiovascular events. The 2019 European Society of Cardiology/European Atherosclerosis Society guidelines recommend absolute LDL-C treatment targets of <100 mg/dL, <70 mg/dL and <55 mg/dL according to coexisting patient risk factors.
Objective: To clarify the difference in the plaque characteristics of coronary lesions associated with these LDL-C levels in statin-treated patients.
Background: High triglyceride (TG) levels have been demonstrated to be a risk factor for coronary artery disease. This study aimed to clarify the impact of TG levels on the characteristics of coronary plaques.
Methods: A total of 850 consecutive patients who underwent optical coherence tomography (OCT) imaging of the culprit lesion were included.
Characteristics of carotid atherosclerosis in patients with plaque erosion.
J Thromb Thrombolysis
August 2021
Plaque erosion (PE) is a major underlying mechanism of acute coronary syndrome (ACS). Patients with PE may have less systemic atherosclerosis. We aimed to clarify the status of carotid atherosclerosis in patients with PE.
View Article and Find Full Text PDFAchilles tendon thickening (ATT) is a marker of high risk for coronary artery disease (CAD). However, the association between the presence of ATT and the incidence of cardiovascular events in patients with CAD is unclear. A total of 406 consecutive patients who underwent percutaneous coronary intervention (PCI) and ATT assessment were analyzed.
View Article and Find Full Text PDFBackground: The difference in type of antibiotics and susceptibility of to antibiotics may influence warfarin anticoagulation. However, these influences have not been clarified in clinical settings.
Objectives: This study aimed to investigate association the between the prothrombin time-international normalized ratio (PT-INR) and concomitant use of antibiotics in a real-world population of warfarin users.
Background And Aims: Endothelial glycocalyx covers the endothelium and maintains vascular integrity. However, its association with the severity and vulnerability of coronary artery disease (CAD) remains to be elucidated.
Methods: A total of 259 consecutive patients with stable CAD requiring percutaneous coronary intervention (PCI) were prospectively enrolled.
Objectives: To assess the clinical significance of a novel optical coherence tomography (OCT)-derived volumetric parameter of stent expansion by comparing it with the conventional parameters in real-world practice.
Background: The clinical significance of novel parameters in real-world practice including longer and smaller stents remains to be elucidated.
Methods: A total of 226 de novo lesion treated with drug-eluting stents in 208 consecutive patients were enrolled.
Distinct clinical characteristics have been demonstrated in patients with plaque erosion as compared with those with plaque rupture. We reasoned that greater physical activity might influence the onset of plaque erosion. In total, 97 consecutive patients with non ST-segment elevation acute coronary syndrome (ACS) who underwent optical coherence tomography (OCT) imaging of the culprit lesion were enrolled.
View Article and Find Full Text PDFBackground: The pathophysiology and chronological course of atherosclerosis seems to be different between men and women due to biological differences, and age and gender differences in plaque composition of coronary lesions remain to be elucidated.
Methods and results: A total of 860 consecutive patients with a median age of 69 years (IQR, 60-78 years) who underwent optical coherence tomography (OCT) of culprit lesions was included. The composition of culprit plaque on OCT was compared between female (n=171) and male (n=689) subjects in younger (<70 years old) and elderly (≥70 years old) patients.
Background: High lipoprotein (a) [Lp(a)] levels are an independent factor for worse prognosis in patients with coronary artery disease (CAD). However, the association between serum Lp(a) level and coronary plaque vulnerability remains to be determined.
Methods: A total of 255 consecutive patients with CAD who underwent optical coherence tomography imaging of culprit lesions were included.
Background And Aims: Intraplaque cholesterol crystal (CC) is recognized as a component of vulnerable plaques. However, the clinical characteristics of patients with CC and the impact of CC on clinical events remain unknown.
Methods: A total of 340 consecutive patients who underwent optical coherence tomography (OCT) imaging of culprit lesions were included in the study.
Article Synopsis
- The primary reason chemotherapy fails in patients with chronic gastritis and peptic ulcers caused by H. pylori is resistance to clarithromycin due to mutations in the 23S rRNA gene.
- A novel non-invasive method using sequencing of the 23S rRNA gene allows accurate detection of both CAM-resistant and -susceptible H. pylori by analyzing DNA from fecal samples.
- The study found that a significant percentage of patients with treatment failure carry mutations in the 23S rRNA gene, indicating that this new diagnostic approach may improve the detection of CAM-resistant infections and lead to more effective therapy.