Publications by authors named "Ayalur Kodakara Kochugovindan Unni"
Article Synopsis
- The study explores the role of gut-brain interactions in multiple sclerosis (MS) by focusing on the proinflammatory protein glia maturation factor-β (GMF-β) and its activation, which exacerbates experimental autoimmune encephalomyelitis (EAE).
- Researchers developed an inhibitor, GMFBI.1, which blocks the phosphorylation of GMF-β, showing that its administration can significantly suppress symptoms of EAE.
- The research findings highlight the importance of gut bioavailability of GMFBI.1, demonstrating that restoring its levels in the gut leads to complete reversal of EAE symptoms and associated molecular health improvements.
Orally delivered molecularly targeted small-molecule drugs play a significant role in managing cancer as a chronic disease. However, due to the poor oral bioavailability of some of these molecules, high-dose administration is required leading to dose-limiting toxicity especially when delivered daily for a long duration. Here, we report an oral nanoformulation for small-molecule multi-kinase inhibitor, sorafenib tosylate, showing nearly two fold enhancement in the oral bioavailability and enhanced therapeutic efficacy with a better safety profile compared to the current clinical formulation.
View Article and Find Full Text PDFtracking of transplanted stem cells to monitor their migration, biodistribution, and engraftment in the host tissue is important for assessing the efficacy of stem cell therapeutics. Here, we report a biomineral nanocontrast agent, iron doped calcium phosphate nanoparticles (nCP:Fe), for the tracking of stem cells in brain using magnetic resonance imaging (MRI). We have synthesized ∼100 nm sized nCP nanoparticles doped with 9.
View Article and Find Full Text PDFSignificance of elevated Prohibitin 1 levels in Multiple Sclerosis patients lymphocytes towards the assessment of subclinical disease activity and its role in the central nervous system pathology of disease.
Int J Biol Macromol
April 2018
Article Synopsis
- MS is an autoimmune-neurodegenerative disorder where treating lymphocyte activity is key, with Prohibitin 1 (PHB) being significant in managing the disease due to its role in controlling reactive oxygen species (ROS).
- Recent studies show that PHB levels are significantly higher in both brain tissue of a mouse model for MS (EAE) and in the lymphocytes of MS patients during acute and relapsing phases compared to remission.
- The elevated PHB levels in these conditions suggest it could be a useful biomarker for evaluating disease status and predicting potential relapses in MS patients.
Localized and controlled delivery of chemotherapeutics directly in brain-tumor for prolonged periods may radically improve the prognosis of recurrent glioblastoma. Here, we report a unique method of nanofiber by fiber controlled delivery of anti-cancer drug, Temozolomide, in orthotopic brain-tumor for one month using flexible polymeric nano-implant. A library of drug loaded (20 wt%) electrospun nanofiber of PLGA-PLA-PCL blends with distinct in vivo brain-release kinetics (hours to months) were numerically selected and a single nano-implant was formed by co-electrospinning of nano-fiber such that different set of fibres releases the drug for a specific periods from days to months by fiber-by-fiber switching.
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