Publications by authors named "Ayako Takai-Yumine"
Article Synopsis
- * Researchers hypothesized that the aryl hydrocarbon receptor (AHR) might trigger IL-37 production in skin cells (keratinocytes), leading to experiments that showed AHR activation could boost IL-37 levels.
- * The study also found that increased IL-37 can suppress IL-33, a cytokine linked to inflammatory skin diseases, and that treatments with agents like tapinarof and ferment filtrate could potentially help manage conditions such as atopic dermatitis and psoriasis by influencing this AHR/IL-37 pathway.
Psoriasis is a chronic inflammatory skin disease, and its immune mechanism has been profoundly elucidated. Biologics targeting interleukin (IL)-23 have prevented the development of psoriasis. As major sources of IL-23, dendritic cells (DCs) play a pivotal role in psoriasis; however, the regulatory mechanism of IL-23 in DCs remains unclear.
View Article and Find Full Text PDFNeurofibromatosis type 1 is an autosomal dominant genetic disorder caused by mutation in the neurofibromin 1 (NF1) gene. Its hallmarks are cutaneous findings including neurofibromas, benign peripheral nerve sheath tumors. We analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous neurofibroma and found excessive expression of collagen and reduced expression of MMP1.
View Article and Find Full Text PDF