Publications by authors named "Ayako Oosawa-Tatsuguchi"
Article Synopsis
- Primary liver cancer shows significant variation in causes, tissue structure, and treatment responses; understanding this can aid personalized treatments.
- The study analyzed 259 liver cancer samples from Japanese patients, focusing on protein profiling, genetic mutations, and gene expression to uncover molecular differences.
- Researchers identified three proteomic subclasses of tumors (R1, R2, R3) with distinct characteristics and prognoses, proposing 22 proteins as potential markers for better treatment decisions.
Cancers (Basel)
February 2021
Article Synopsis
- Gallbladder cancer (GBC) is a rare and deadly disease typically diagnosed in advanced stages, prompting a need for better molecular understanding and classification.
- Researchers conducted a detailed transcriptome analysis of GBC samples, revealing two subclasses based on tumor microenvironment (TME) gene expression, with TME-rich tumors linked to poorer prognosis and higher recurrence rates.
- Key findings included the overexpression of genes related to epithelial-to-mesenchymal transition (EMT) and inflammation in TME-rich tumors, along with significant mutation profiles that suggest targeted pathways for potential therapies.
