Analysis of adipose tissues and stromal vascular cells in a murine arthritis model.

Purpose: Changes in body composition in rheumatoid arthritis (RA), including a reduction in skeletal muscle mass and the accumulation of visceral fat, have been identified, and the interaction between immune abnormality and metabolic disorders has received much attention. The effect of a high-fat (HF) diet and the role of adipose tissue in an arthritis model were investigated.

Methods: The effect of an HF diet on the histopathology of joints in murine type II collagen-induced arthritis (CIA) was evaluated.