Publications by authors named "Ayaka Yawata"
Article Synopsis
- Methadone is a unique µ-opioid receptor agonist, and its distinct effects compared to other opioids like fentanyl and morphine are still debated, particularly regarding NMDA receptor involvement.
- In research, it was found that fentanyl mimicked methadone’s effects more closely than morphine did, and methadone did not activate NMDA receptors like previously suggested.
- The study indicates that methadone's effects are likely related to its ability to cause β-arrestin recruitment at µ-opioid receptors, a mechanism similar to fentanyl, rather than through NMDA receptor blockade.
