[Serotonin 5- HT4 receptor agonist (mosapride citrate)].

Irritable bowel syndrome is a functional gastrointestinal disorder characterized by abnormal sensation and motility in the lower gastrointestinal tract. In constipation-type irritable bowel syndrome, decreased bowel motility causes stagnation of feces and gas, resulting in enhanced pain sensation of the bowel. Mosapride citrate is a selective serotonin 5- HT4 receptor agonist and enhances propulsive activity throughout the gastrointestinal tract.

Placement of the Bravo wireless pH monitoring capsule onto the gastric wall under endoscopic guidance.

Background: The Bravo system was designed mainly to monitor esophageal pH, and there have been no reports on gastric pH monitoring using this system.

Objective: To place the Bravo capsule on the gastric wall and monitor gastric pH.

Design: Experimental clinical trial with the cooperation of volunteers.

Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy.

Aim: To objectively evaluate the effect of TJ-68 on colonic spasms during colonoscopy.

Methods: One hundred and one patients subjected to screening colonoscopy were randomly assigned to two groups: TJ-68 in 51 subjects and saline as the control in 50. The endoscope was inserted into the sigmoid colon, then a spastic region was identified and the tip of the colonoscope was positioned at a distance of about 10 mm from the spastic region.