Publications by authors named "Ayaka Saeki"
Lynch syndrome is an autosomal dominant inherited disorder caused by a germline pathogenic variant in DNA mismatch repair genes, resulting in multi-organ cancer. Annual transvaginal ultrasonography and endometrial biopsy are recommended for endometrial cancer surveillance in patients with Lynch syndrome in several guidelines; however, evidence is limited. Here, we present the case of a 51-year-old woman with endometrial cancer who underwent robot-assisted laparoscopic simple hysterectomy at an early stage detected by Lynch syndrome surveillance.
View Article and Find Full Text PDFId4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
Biochim Biophys Acta Mol Cell Res
February 2023
Article Synopsis
- Salivary glands maintain balance through cell differentiation, proliferation, and interactions, and are commonly affected in Sjögren's syndrome (SS) and IgG4-related disease (IgG4-RD), but their homeostasis in these conditions isn't well understood.
- Research on Id4, a protein regulating cell differentiation, showed that mice lacking Id4 had smaller salivary glands and experienced dry mouth symptoms, indicating Id4's role in gland development and function.
- Id4 levels were found to be significantly lower in salivary glands of IgG4-RD patients, not in SS patients, and a specific microRNA (miR-486-5p) may regulate Id4 in these lesions, highlighting the potential