Switching to brolucizumab from aflibercept in age-related macular degeneration with type 1 macular neovascularization and polypoidal choroidal vasculopathy: an 18-month follow-up study.

Purpose: To assess the effect of switching to brolucizumab from aflibercept on eyes with type 1 macular neovascularization (MNV) and polypoidal choroidal vasculopathy (PCV) at 18 months.

Methods: This study was a retrospective, observational case series that included 19 eyes of 19 patients with type 1MNV and 23 eyes of 22 patients with PCV. We compared the injection intervals, visual acuity, total lesion size, and the number of polypoidal lesions between baseline and 18 months.

Hydroxychloroquine's Early Impact on Cone Density.

Purpose: To evaluate early effects of hydroxychloroquine (HCQ) on the retina using adaptive optics (AO).

Methods: This was a prospective observational single-center study of 29 eyes of 29 patients who had been treated with HCQ for the first time and followed with AO for a minimum of two years. Cone counting was performed in 4 quadrants, nasal, temporal, superior, and inferior, at 0.

Using optical coherence tomography angiography to guide myopic choroidal neovascularization treatment: a 3-year follow-up study.

Purpose: To report the long-term changes of the size of myopic choroidal neovascularization (mCNV) using optical coherence tomography angiography (OCTA).

Methods: This was a retrospective, observational case study of eleven eyes in eleven patients with mCNV followed with OCTA for a minimum of 3 years. The flow area of mCNV on OCTA, the size of chorioretinal atrophy (CRA) and central choroidal thickness were analyzed.

Corneal topographic changes after blepharoptosis surgery in patients with deepening of the upper eyelid sulcus.

Purpose: We analyzed the corneal topography before and after blepharoptosis surgery and examined whether there was a difference in the corneal topographic changes with and without deepening of the upper eyelid sulcus (DUES).

Study Design: Retrospective study.

Methods: A total of 23 eyes of 23 patients (6 men and 17 women) were enrolled in this study.

Factors influencing the reduction in corneal endothelial cells after Ex-Press surgery.

Purpose: We investigated the factors that influence the reduction in corneal endothelial cells after Ex-Press surgery.

Methods: This was a retrospective study. We included patients who had undergone Ex-Press surgery and were followed up for > 2.

Detecting latitudinal and altitudinal expansion of invasive bamboo and (Poaceae) in Japan to project potential habitats under 1.5°C-4.0°C global warming.

Rapid expansion of exotic bamboos has lowered species diversity in Japan's ecosystems by hampering native plant growth. The invasive potential of bamboo, facilitated by global warming, may also affect other countries with developing bamboo industries. We examined past (1975-1980) and recent (2012) distributions of major exotic bamboos ( and ) in areas adjacent to 145 weather stations in central and northern Japan.

Spontaneous atrial fibrillation initiated by tyramine in canine atria with increased sympathetic nerve sprouting.

Background: Chronic left ventricular myocardial infarction (LVMI) promotes atrial and pulmonary veins (PV) sympathetic nerve sprouting.

Objectives: To test the hypothesis that sympathetic stimulation with tyramine initiates atrial fibrillation (AF) by early after depolarization (EAD)-mediated triggered activity at the left atrial PV (LAPV) junction.

Methods: LVMI was created in 6 dogs and 6 dogs served as controls.