Publications by authors named "Ayaka Miyake"

Article Synopsis
  • In Japan, the treatment of schizophrenia has historically involved polypharmacy, which is less common globally, and this issue persisted until the introduction of clozapine in 2009.
  • A study examining changes in psychopharmacotherapy over 12 years revealed significant reductions in average medication doses and a notable increase in antipsychotic monotherapy following the introduction of clozapine.
  • By 2020, the prescription of clozapine rose to 37.3%, contributing to a decline in the use of multiple antipsychotics, indicating that clozapine could optimize schizophrenia treatment in Japan.
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Improving the biomass retention and the sludge system stability to promote the full-scale application of anammox process is the focus of current related research. In this study, a calcium silicate hydrate functional material with calcium-releasing ability and weak alkalinity was used for an enhanced anammox process. In the long-term operation, an increase in the nitrogen removal rate (NRR) from 2.

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Described herein is a highly enantioselective synthesis of fused piperidine and pyrrolidine derivatives with all-carbon stereogenic centers. The enantioselective reductive amination from C(s)-symmetric 1,3-dione derivatives proceeded in a highly stereoselective manner by taking advantage of the desymmetrization approach to afford fused heterocycles with contiguous stereogenic centers in good to excellent enantioselectivities (up to 98% ee).

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Proline cis-trans isomerization is known to play a key role in the rate-determining steps of protein folding. It is thus very important to understand the influence of environments, not only bulk solutions but also microenvironments such as interfaces, on the isomerization reaction of proline peptides. Here we present two HPLC methods for measurements of kinetic and equilibrium parameters for the isomerization reactions in bulk solutions and at liquid/solid interfaces.

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In the present study, we examined the effect of ACTH on the immobilization of rats in the forced swim test and hippocampal cell proliferation after administration of the 5-HT1A receptor agonist, R-(+)-8-hydroxy-2-di-n-propylamino tetralin ((+)-8-OH-DPAT). Chronic treatment with (+)-8-OH-DPAT (0.01-0.

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Article Synopsis
  • ACTH-treated rats are used as a model for studying depression that doesn't respond to tricyclic antidepressants.
  • Treatment with ACTH lowered the number of new brain cells in the hippocampus and reduced brain-derived neurotrophic factor (BDNF) levels, both crucial for neurogenesis.
  • Combining imipramine, lithium, and electroconvulsive treatment helped reverse these effects, indicating a potential pathway to address antidepressant-resistant depression through enhanced neurogenesis.
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