Publications by authors named "Ayaka Furuta"
Background: LR11 is a member of the low-density lipoprotein (LDL) receptor family with high expression in neurons. Some cell surface LR11 is cleaved and secreted into the cerebrospinal fluid (CSF) as soluble LR11 (sLR11). Patients with Alzheimer's disease (AD), particularly apolipoprotein E4 carriers, have high CSF-sLR11 and low CSF-amyloid β (Aβ) concentrations.
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- LCAT deficiency is a rare genetic disorder that causes extremely low cholesterol levels and nephrotic syndrome, with specific lipoprotein changes noted in familial cases.
- This case study focuses on a 67-year-old man who developed acquired LCAT deficiency characterized by undetectable LCAT activity and severe renal issues, along with a unique lipoprotein profile.
- Treatment with prednisolone led to remission of his symptoms, highlighting that while LCAT activity levels correlate with kidney problems, outcomes can vary significantly between genetically inherited and acquired forms of the disorder.
Background: Rapid turnover proteins (RTPs), such as transthyretin (TTR), retinol binding protein (RBP), and transferrin (Tf), provide an accurate assessment of nutritional status but are susceptible to inflammation. Lipid-related markers, which have short half-lives in serum, may be better suited for nutritional assessment. We sought to identify sensitive nutritional markers unaffected by inflammation.
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