Publications by authors named "Ayah N Faraj"
Article Synopsis
- Cucurbiturils (CB), specifically cucurbit[7]uril (CB7), can form stable complexes with drug molecules such as phenylephrine hydrochloride in water, demonstrating high binding affinity.
- The structure of this complex was analyzed using H NMR spectroscopy, revealing that the aromatic part of phenylephrine fits into the hydrophobic cavity of CB7.
- Computational DFT calculations supported these findings, highlighting strong intermolecular interactions and that the protonated form of phenylephrine binds preferentially, causing a pH-dependent shift in the complex.
