Publications by authors named "Aya Samir Ayed"
Article Synopsis
- The study investigates the anti-cancer effects of phthalimide-1,2,3-triazole compounds with sulfonamide elements on MCF-7 (breast) and PC3 (prostate) cancer cells.
- Several compounds were created using an efficient click synthesis method, showing promising results with some compounds exhibiting significant cytotoxicity against MCF-7 cells.
- Notably, compound 6c showed the highest effectiveness, causing cell death and disrupting the cell cycle in MCF-7 cells, suggesting it could be a potential breast cancer treatment.
c-MET and STAT-3 are significant targets for cancer treatments. Here, we describe a class of very effective dual STAT-3 and c-MET inhibitors with coumarin-based thiazoles (3a-o) as its scaffold. Spectroscopic evidence (NMR, HRMS, and HPLC) validated the structural discoveries of the new compounds.
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