Publications by authors named "Aya Nishiwaki"

Article Synopsis
  • The study investigated risk factors for cytomegalovirus (CMV) infection in rheumatic disease patients undergoing immunosuppressive therapy and sought a diagnostic cut-off for CMV pp65 antigenemia.
  • A total of 261 patients were analyzed, revealing a 54% prevalence of CMV infection, with three key risk factors identified: age over 60, low lymphocyte counts (<1000/μL), and steroid pulse therapy.
  • The researchers propose a cut-off of more than five CMV-positive cells per two slides as a threshold for diagnosing CMV disease and recommend antiviral treatment for affected patients.
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Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated gene expression pattern linked to various clinical statuses with a high cellular resolution. Here, we conducted a large-scale transcriptome study with 6,386 RNA sequencing data covering 27 immune cell types from 136 SLE and 89 healthy donors.

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Article Synopsis
  • The study focuses on using artificial intelligence to improve the diagnosis of IgG4-related disease (IgG4-RD), a rare and complex condition that requires specialized knowledge.
  • Researchers collected data from 602 patients diagnosed with IgG4-RD and 204 patients with other conditions, applying machine learning techniques like decision trees and random forests to distinguish between them.
  • Results showed high accuracy in classifying IgG4-RD using patient characteristics and blood test results, achieving AUROC curve values of 0.974 when including serum IgG4 levels, indicating that AI can help reduce disparities in diagnosing rare diseases.
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After the infection of foot-and-mouth disease outbreaks in Miyazaki, Japan, in 2010, cattle and swine were slaughtered and buried in a site of 100 ha, where weed control is difficult and costly since lands are unlevelled and prohibited to be plowed for 3 years. To consider the adaptability of napiergrass (Pennisetum purpureum Schumach.) to the animal burial site for weed control, two napiergrass varieties, normal Wruk wona (WK) and dwarf late-heading variety (DL), were transplanted, compared with sowing of maize (MZ) and sorghum (SR) in both burial (BU) and neighboring bordered area (BO) in mid-June 2011.

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Unilateral introgression from diploids to tetraploids has been hypothesized to be an important evolutionary mechanism in plants. However, few examples have been definitively identified, perhaps because data of sufficient depth and breadth were difficult to obtain before the advent of affordable high-density genotyping. Throughout Japan, tetraploid Miscanthus sacchariflorus and diploid Miscanthus sinensis are common, and occasionally hybridize.

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Global soil carbon (C) stocks account for approximately three times that found in the atmosphere. In the Aso mountain region of Southern Japan, seminatural grasslands have been maintained by annual harvests and/or burning for more than 1000 years. Quantification of soil C stocks and C sequestration rates in Aso mountain ecosystem is needed to make well-informed, land-use decisions to maximize C sinks while minimizing C emissions.

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The nodulation tendency and community structure of indigenous bradyrhizobia on Rj genotype soybean cultivars at cultivation temperatures of 33/28°C, 28/23°C, and 23/18°C for 16/8 h (day/night degrees, hours) were investigated using 780 bradyrhizobial DNA samples from an Andosol with 13 soybean cultivars of four Rj genotypes (non-Rj, Rj(2)Rj(3), Rj(4), and Rj(2)Rj(3)Rj(4)). A dendrogram was constructed based on restriction fragment length polymorphism of the PCR products (PCR-RFLP) of the 16S-23S rRNA gene internal transcribed spacer region. Eleven Bradyrhizobium U.

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Premise Of The Study: Looming petroleum shortages and projected negative impacts of human-induced climate change may be partly alleviated by the development and use of bioenergy feedstock crops. Miscanthus ×giganteus, a highly productive sterile triploid hybrid grass that was discovered in Japan several decades ago, has considerable potential as an alternative source of energy. Given the risks, however, involved in the reliance upon production of one clone of this hybrid, which is a natural cross between Miscanthus sacchariflorus and Miscanthus sinensis, for lignocellulosic bioenergy production, natural occurrences of triploidy were investigated in sympatric populations of tetraploid M.

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Background And Aims: Clonal fragments of the rhizomatous dwarf bamboo Sasa palmata, which widely predominates in temperate regions of Japan, were grown under heterogeneous resource conditions such as gap understories or nutrient-patchy grassland. Clonal fragments develop multiple ramets with long rhizomes and appear to be physiologically integrated by the translocation of assimilates. The glasshouse experiment reported here was designed to clarify the mechanisms of physiological integration of nitrogen more precisely.

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