Efficacy and limitations of additional steroid pulse therapy in IgA nephropathy patients whose hematuria did not remit on tonsillectomy and protocol steroid pulse therapy.

Background: Hematuria is the essential symptom of IgA nephropathy that has been suggested to be associated with long-term renal prognosis, Tonsillectomy and steroid pulse therapy (TSP), which is widely practiced in Japan, is effective for achieving hematuria remission. However, some cases are refractory to TSP, and additional steroid pulse therapy (SP) administered to these cases to achieve remission of hematuria. Nonetheless, the clinical significance of additional SP is unknown.

Benign angiopathy of the central nervous system associated with phenytoin intoxication.

We report a patient with epilepsy who presented with acute onset of left hemiparesis associated with phenytoin intoxication due to interaction with clobazam. Magnetic resonance angiography of the head revealed stenosis of the M2 segment of the right middle cerebral artery, whereas an erythrocyte sedimentation rate and cerebrospinal fluid analysis were normal, being consistent with a diagnosis of benign angiopathy of the central nervous system. The patient exhibited an elevated plasma level of thrombin-antithrombin III complex along with a marginally increased plasma concentration of soluble E-selectin.

Elevated pitch perception owing to carbamazepine-activating effect on the peripheral auditory system: auditory brainstem response study.

Auditory disturbance is an uncommon side effect of carbamazepine, the pathophysiologic mechanism of which has not been clearly elucidated. We performed an auditory brainstem response study in a 9-year-old boy with epilepsy who had suffered from falsely higher pitch perception immediately after the start of carbamazepine treatment. The auditory brainstem response results showed that both the peak latency of wave V and the interpeak latencies of waves I to V were significantly prolonged with 85 dB HL click stimulation and that the peak amplitudes of the waves were noticeably elevated, particularly with lower click stimulation intensity.