Publications by authors named "Aya Kido"
Gastric cancer (GC) is characterized by significant intratumoral heterogeneity, and stem cells are promising therapeutic targets. Despite advancements in spatial transcriptome analyses, unexplored targets for addressing cancer stemness remain unknown. This study aimed to identify Nuclear Factor IX (NFIX) as a critical regulator of cancer stemness in GC and evaluate its clinicopathological significance and function.
View Article and Find Full Text PDFIntroduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of malignancy, with poor prognosis and rising incidence. IQ motif containing GTPase-activating protein 3 (IQGAP3) is a member of the IQGAPs family of scaffolding proteins that govern multiple cellular activities like cytoskeletal remodeling and cellular signal transduction. This study aimed to analyze the expression and biological function of IQGAP3 in PDAC.
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- - The study investigates KIF18B, a gene previously unreported in gastric cancer (GC), particularly in the context of gastric mucin phenotype GC, which is prevalent in Japan and associated with mortality.
- - Analysis involved RNA sequencing and immunohistochemistry on 96 GC cases, revealing KIF18B expression in 54% of cases and its correlation with poor survival rates, as well as associations with other important molecules.
- - Functional studies showed that silencing KIF18B in GC cells enhanced growth and altered the expression of key proteins involved in cell behavior, suggesting it could be a significant prognostic marker and contribute to understanding the cancer's development.
Article Synopsis
- MCM4, previously linked to gastric cancer, shows strong nuclear expression in upper tract urothelial carcinoma (UTUC), with 62% of cases exhibiting this overexpression and correlating with aggressive tumor characteristics.
- High MCM4 levels in UTUC are positively associated with poor prognosis, high tumor grade, and invasive characteristics, as well as with other cancer markers like Ki-67 and p53.
- MCM4 immunocytochemistry enhances urine cytology diagnostics for UC, suggesting its potential as a predictive biomarker for tumor progression and survival outcomes.
βIII-Tubulin, encoded by the TUBB3 gene, is a microtubule protein. We previously reported that TUBB3 is overexpressed in renal cell carcinoma. We investigated the clinicopathological significance of TUBB3 in upper tract urothelial carcinoma (UTUC) by immunohistochemistry.
View Article and Find Full Text PDFPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer and the third leading cause of cancer-related deaths. Therefore, there is an urgent need for a novel molecular target for the treatment of PDAC. Kinesin family member C1 (KIFC1) belongs to the kinesin superfamily proteins and has been reported to be involved in the pathogenesis of a wide variety of carcinomas.
View Article and Find Full Text PDFBackground: Concurrent breast cancer and malignant lymphoma is a rare phenomenon. This report describes malignant lymphoma that was incidentally diagnosed from a sentinel lymph node biopsy (SLNB) during breast cancer surgery.
Case Presentation: A 73-year-old woman with a history of ovarian cancer and diabetes presented with right focal asymmetric density on a mammogram acquired during routine breast cancer screening.
Article Synopsis
- The sarcomatoid variant of urothelial carcinoma is a rare but aggressive cancer that infiltrates surrounding tissues, with limited case reports available.
- A 75-year-old woman had a left kidney tumor that spread to nearby organs, leading to the surgical removal of multiple affected areas.
- After surgery, she underwent chemotherapy but unfortunately passed away five months later, marking the first known instance of this cancer variant invading the pancreas and descending colon.
Introduction: Gastric cancer (GC) is a leading cause of cancer-related death worldwide. This study focused on minichromosome maintenance 4 (MCM4), a DNA helicase component that functions in DNA replication. Using spheroid colony formation, having a colony rich in cancer stem cells, this study aimed to investigate the clinicopathological importance of MCM4.
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- Esophageal cancer is a major cause of cancer deaths globally, with a need for new targeted therapies, particularly for esophageal squamous cell cancer (ESCC), where the role of protocadherin (PCDH) B9 has been investigated.
- In a study involving 128 cases, PCDHB9 was assessed via immunohistochemistry, with 31.3% of cases showing high expression, correlating with advanced disease features.
- The research indicates that PCDHB9 not only promotes tumor growth but also alters the expression of various integrins and cadherins, making it a promising biomarker and potential target for ESCC treatment.
Tumor-associated macrophages (TAMs) contribute to the progression and mortality of various malignancies. We reported that high numbers of infiltrating TAMs were significantly associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma (ESCC). In our previous investigation of TAMs' actions in ESCC, we compared gene expression profiles between peripheral blood monocyte (PBMo)-derived macrophages and TAM-like macrophages stimulated with conditioned media of ESCC cell lines.
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