Publications by authors named "Aya Ghnaim"
Background: Obesity and type 2 diabetes (T2D) promote inflammation, increasing the risk of colorectal cancer (CRC). High-fat diet (HFD)-induced obesity is key to these diseases through biological mechanisms. This study examined the impact of genetic background on the multimorbidity of intestinal cancer, T2D, and inflammation due to HFD-induced obesity.
View Article and Find Full Text PDFObesity and its attendant conditions have become major health problems worldwide, and obesity is currently ranked as the fifth most common cause of death globally. Complex environmental and genetic factors are causes of the current obesity epidemic. Diet, lifestyle, chemical exposure, and other confounding factors are difficult to manage in humans.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes mellitus (T2DM) is a growing global health crisis affecting insulin use, with an estimated 700 million diagnoses by 2045, leading to complications like heart disease and inflammation.
- A study using 207 genetically diverse Collaborative Cross (CC) mice examined how a high-fat diet (HFD) impacts blood glucose clearance and organ weights, finding that HFD led to decreased glucose clearance and different weight responses between male and female mice.
- The research highlights the importance of genetic factors in T2DM, showing that female liver weight increased significantly with HFD, while males exhibited higher heritability for weight changes under the same dietary conditions.
Background: Type 2 diabetes (T2D) is an adult-onset and obese form of diabetes caused by an interplay between genetic, epigenetic, and environmental components. Here, we have assessed a cohort of 11 genetically different collaborative cross (CC) mouse lines comprised of both sexes for T2D and obesity developments in response to oral infection and high-fat diet (HFD) challenges.
Methods: Mice were fed with either the HFD or the standard chow diet (control group) for 12 weeks starting at the age of 8 weeks.