Publications by authors named "Aya Federman Gross"
Article Synopsis
- Cnidaria, which includes animals like sea anemones and jellyfish, are the oldest venomous creatures, but their toxin structures and functions are not well understood.
- Recent research has explored the evolutionary history of various cnidarian toxin families, revealing that these toxins are mostly conserved due to strong negative selection, contrasting with rapidly evolving toxins in other animal lineages.
- The study also identifies newly discovered small cysteine-rich peptides (SCRiPs) as potent neurotoxins in corals, highlights the evolutionary link between different toxin types in sea anemones, and suggests a connection between adaptive genetic changes and new toxin functions.
The superoxide (O(·-) 2)-generating NADPH oxidase of phagocytes consists of a membrane component, cytochrome b 558 (a heterodimer of Nox2 and p22 (phox) ), and four cytosolic components, p47 (phox) , p67 (phox) , p40 (phox) , and Rac. The catalytic component, responsible for O(·-) 2 generation, is Nox2. It is activated by the interaction of the dehydrogenase region (DHR) of Nox2 with the cytosolic components, principally with p67 (phox) .
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