Publications by authors named "Aya Ebdalla"
Article Synopsis
- Extreme heat from climate change is linked to a rise in infectious diseases and heat-related health issues, making it crucial to understand how heat, inflammation, and disease interact.
- In neonates, the TRPV1 channel, sensitive to heat and inflammation, affects breathing and may make them more prone to seizures during heat stress.
- Research on neonatal rats showed that inflammation from LPS lowers seizure thresholds during heat stress; blocking TRPV1 reduced seizure risk and improved breathing efficiency, indicating that inflammation worsens respiratory issues and seizure susceptibility through TRPV1 in vagus neurons.
Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. SCN1A encodes Na1.1, a neuronal voltage-gated Na channel that is highly expressed throughout the central nervous system.
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