Publications by authors named "Aya Bar David"
Article Synopsis
- This study investigates the role of MRI in detecting early changes in white matter among patients with genetic Creutzfeldt-Jakob disease (gCJD) and asymptomatic carriers of the E200K mutation.
- Researchers found that symptomatic gCJD patients showed distinct alterations in white matter metrics compared to healthy relatives, specifically in terms of higher mean diffusivity and lower fractional anisotropy values.
- Among healthy relatives, those carrying the E200K mutation with elevated tau protein levels in cerebrospinal fluid exhibited significant white matter changes, suggesting that further monitoring could reveal if these changes predict the development of symptomatic gCJD.
Background: The Unified Dyskinesia Rating Scale (UDysRS) is a well-established tool for producing comprehensive assessments of severity and disability associated with dyskinesia in patients with Parkinson's disease (PD). The scale was originally developed in English, and a broad international effort has been undertaken to develop and validate versions in additional languages. Our aim was to validate the Hebrew version of the UDysRS.
View Article and Find Full Text PDFBackground: Worldwide prevalence estimates of Huntington disease (HD) vary widely, with no reliable information regarding the Jewish population in Israel.
Methods: This specialized tertiary single-center cross-sectional study assessed clinical, cognitive, and demographic characteristics of 84 HD patients who were treated at the Movement Disorder Unit of the Tel Aviv Medical Center, Israel.
Results: Our cohort was composed of one-third Ashkenazi Jews, 27% Mountain Jews (Caucasus Jews), 18% Sephardi Jews, and 21% Karaites, with both Mountain Jews and Karaites over-represented compared to their relevant proportion in the population of the state of Israel, which is less than 1%.