The role of angiotensin-converting enzyme 2 () genetic variations in COVID-19 infection: a literature review.

Background: The angiotensin-converting enzyme-2 () is recognized to be the fundamental receptor of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), responsible for the worldwide Coronavirus Disease-2019 (COVID-19) epidemic. However, genetic differences between people besides racial considerations and their relation to disease susceptibility are still not fully elucidated.

Main Body: To uncover the role of in COVID-19 infection, we reviewed the published studies that explore the association of COVID-19 with the functional characteristics of and its genetic variations.