Publications by Axier Pineno-Ramos

Publications by authors named "Axier Pineno-Ramos"

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Lethal mutagenesis of an RNA plant virus via lethal defection.

Luis Díaz-Martínez Isabel Brichette-Mieg Axier Pineño-Ramos Guillermo Domínguez-Huerta Ana Grande-Pérez

Sci Rep

January 2018

Lethal mutagenesis is an antiviral therapy that relies on increasing the viral mutation rate with mutagenic nucleoside or base analogues. Currently, the molecular mechanisms that lead to virus extinction through enhanced mutagenesis are not fully understood. Increasing experimental evidence supports the lethal defection model of lethal mutagenesis of RNA viruses, where replication-competent-defectors drive infective virus towards extinction.

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