Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.

Diminished activity of 5,10 methylenetetrahydrofolate reductase (MTHFR), a regulatory enzyme of homocysteine metabolism, may predispose to coronary artery disease (CAD). In a case-control study we determined the prevalence of two common MTHFR polymorphisms, C677T and A1298C, in 161 male patients under the age of 50 years with angiographically documented CAD and compared it to that in 211 healthy controls. Genotyping was also performed in a random population sample, consisting of 149 men and 121 women at an average age of 40 years.

[Congestive cardiomyopathy after a 10-year observation].

A progress in the Polish cardiosurgery promising survival has led to the analysis of patients with congestive cardiomyopathy diagnosed with non-invasive techniques. The study involved 44 patients treated at the III Department of Cardiology in Katowice-Ochojec in 1980-1989. Sixty six percent of these patients were men.

Gutron treatment of patients suffering from essential orthostatic hypotony. Part Three--Hemodynamic-autonomic interactions.

In this communication neurovegetative investigation of circulatory system in essential orthostatic hypotony (EOH) is continued. Our previous polycardiographic and heart rate variability (HRV) studies showed, that hemodynamic alterations in EOH are concerned with impairment of both branches of autonomic system. But hemodynamic-autonomic interactions in EOH are till now not well recognized.

Gutron treatment of patients suffering from essential orthostatic hypotony. Part Two--Autonomic system investigation.

Neurovegative control of circulatory system in essential orthostatic hypotony (EOH) is not well recognized. Therefore, in group of 9 patients (pts) with EOH treated with midodrine (Gutron, Gu) 5 mg i.v.

Gutron treatment of patients suffering from essential orthostatic hypotony. Part One--Hemodynamic non-invasive investigation.

Essential orthostatic hypotony (EOH) seems to present a rarely occurring and not well recognized syndrome. Group of 20 patients (pts) with EOH were treated with midodrine (Gutron, Gu) 5 mg i.v.

[Long-term mexiletine treatment of ventricular arrhythmia in patients after myocardial infarction].

Eighty two patients with ventricular extrasystole (VES) after myocardial infarction had been treated with antiarrhythmic drugs in the half (41 patients) with mexiletine (M) and in the half (41 patients) with other ones. The mortality rate in the M-group was twice time lower than in the other, however this difference was statistically not significant. M was mostly effective in VES of III and IVb degree after Lown's classification and did not cause any deterioration of the left ventricle function.

Mini set for iontophoresis for topical analgesia before injection.

Findings are reported on a prototype mini set for iontophoresis used to topically anesthetise the puncture spot before injection. The anesthetizing drug applied was a 2% solution of lignocaine which was iontophoresed for 10 min at a current of 1-2.5 mA.

Cardiovascular effects of nifedipine--a 4-week treatment in preselected patients with coronary disease.

In 24 patients with coronary ischemic disease the cardiovascular effects of 10-mg tablets of nifedipine given three times daily for 28 days was studied with noninvasive techniques before and after standard work load. Five patients did not complete the study because of drug nontolerance and lack of therapeutic effectiveness. In 19 patients nifedipine has been found to produce positive changes in left ventricle contraction parameters without influencing positively the ECG parameters.