Publications by authors named "Axelle Salcion"
X-linked hypophosphatemia (XLH) is a rare genetic phosphate disorder caused mainly by PHEX mutations. Unlike for children, knowledge of the disease's manifestations in adults is limited. Musculoskeletal symptoms are the main feature of the disease in young adults associated with a heavy burden on patients' life.
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- - The study evaluated the effectiveness of switching from innovator infliximab to its biosimilar in adult patients at Cochin University Hospital, measuring retention rates after three infusions and examining associated factors.
- - Out of 260 patients, an 85% retention rate for the biosimilar was noted, but 23% (59 patients) eventually discontinued due to inefficacy, with no serious side effects reported.
- - Overall, objective disease activity measures showed no significant changes post-switch, although some subjective outcomes, particularly in patients with axial spondyloarthritis, indicated a slight increase, suggesting potential attribution effects rather than actual efficacy changes.