Publications by authors named "Axel Hentsch"
Article Synopsis
- The cannabinoid receptor type 1 (CBR) plays a key role in various bodily functions, including appetite, pain, memory, and body temperature regulation, but our understanding of its cellular signaling and dynamics is limited.
- Researchers developed new fluorescent probes for CBR by using a modular design approach that centers around a diethyl glycine-based building block, making synthesis easier and more efficient.
- Validation of these probes through various assays supports their potential use in real-time imaging studies to explore CBR's localization, movement, and effects in different diseases.
Herein, we report the synthesis and sensing characteristics of 4,4'-methoxy-substituted BODIPY fluorescent probes (O-BODIPYs) 3, 4 and 5 equipped with differently sized benzo-crown ethers (cf. Scheme 1, 3 (benzo-15-crown-5), 4 (benzo-18-crown-6) and 5 (benzo-21-crown7)). O-BODIPYs 3, 4 and 5 exhibited in comparison to their known F-BODIPY analogues 3a, 4a and 5a (cf.
View Article and Find Full Text PDFHerein, we report on highly Ba selective fluorescence sensing in water by a fluorescent probe consisting of a benzo-21-crown-7 as a Ba binding unit (ionophore) and a tetramethylated BODIPY fluorophore as a fluorescence reporter. This fluorescent probe showed a Ba induced fluorescence enhancement (FE) by a factor of 12±1 independently of the pH value and a high Ba sensitivity with a limit of detection (LOD) of (17.2±0.
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