Publications by authors named "Axel Carlsson"
Background: Higher circulating levels of tumor necrosis factor (TNF) alpha receptors 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function.
Aim: To study associations between levels of TNFR1 and TNFR2 and all-cause mortality as well as estimated glomerular filtration rate (eGFR) decline.
Population And Methods: Patients with chronic kidney disease (CKD) stages 3-5 in the Salford Kidney Study were included.
Background: Plasma osteopontin (pOPN) is a promising aging-related biomarker among individuals with and without kidney disease. The interaction between sex, pOPN levels, and global and cardiorenal outcomes among older individuals was not previously evaluated.
Methods: In this study we investigated the association of pOPN with 24-month global mortality, major cardiovascular events (MACEs), MACEs + cardiovascular (CV) mortality, and renal decline among older individuals; we also evaluated whether sex modified observed associations.
Article Synopsis
Purpose: In this study, a comprehensive analysis of costs of chronic kidney disease (CKD) was performed, to understand factors associated with the economic burden of the disease in a multicentre international framework.
Methods: The impact on costs of demographics, socio-economics, clinical, and functional variables was tested in 2204 subjects aged 75 years or more attending outpatient clinics in Europe using a multicentre 2-year prospective cohort study. By means of collected resources consumption and unit cost data a comprehensive cost database was built and then investigated using multilevel regression modeling.
Aims: We aimed to create a predictive model utilizing machine learning (ML) to identify new cases of congestive heart failure (CHF) in individuals with diabetes in primary health care (PHC) through the analysis of diagnostic data.
Methods: We used a sex- and age-matched case-control design. Cases of new CHF were identified across all outpatient care settings 2015-2022 (n = 9098).
Article Synopsis
- The study aimed to investigate the relationship between phase angle (PhA), a marker of hydration and nutritional status, and the development of sarcopenia in older adults.
- It involved 696 participants aged 75 and older, assessing them for sarcopenia and related physical capabilities over 24 months using various tests and methods.
- While lower baseline PhA was observed in those who developed sarcopenia, it was not confirmed as a significant predictor after accounting for other related factors, raising questions about its practical use as an early marker for sarcopenia risk.
Article Synopsis
- The study analyzed the risk of hereditary hemochromatosis (HH) among first-generation and second-generation immigrants in Sweden compared to Swedish-born individuals.
- Over 6 million first-generation and nearly 4.6 million second-generation immigrants were included, with HH diagnosed through patient records from 1998 to 2018.
- Results showed lower overall HH risk for both immigrant groups, with a notable increase in risk only among first-generation men from Western Europe.
Background: Many individuals with hypertension remain undiagnosed. We aimed to develop a predictive model for hypertension using diagnostic codes from prevailing electronic medical records in Swedish primary care.
Methods: This sex- and age-matched case-control (1:5) study included patients aged 30-65 years living in the Stockholm Region, Sweden, with a newly recorded diagnosis of hypertension during 2010-19 (cases) and individuals without a recorded hypertension diagnosis during 2010-19 (controls), in total 507,618 individuals.
Purpose: We aimed at analysing the risk of congestive heart failure (CHF) among first- and second-generation immigrants in younger age groups.
Methods: All individuals aged 18-54 years, n = 3 973 454 in the first-generation study and n = 3 817 560 in the second-generation study, were included. CHF was defined as at least one registered diagnosis in the National Patient Register between 1 January 1998 and 31 December 2018.
Background And Aim: It is crucial to identify a diabetes diagnosis early. Create a predictive model utilizing machine learning (ML) to identify new cases of diabetes in primary health care (PHC).
Methods: A case-control study utilizing data on PHC visits for sex-, age, and PHC-matched controls.
Background: The C-reactive protein/albumin ratio (CAR) seems to mirror disease severity and prognosis in several acute disorders particularly in elderly patients, yet less is known about if CAR is superior to C-reactive protein (CRP) in the general population.
Methods: Prospective study design on the UK Biobank, where serum samples of CRP and Albumin were used. Cox regression analyses were conducted to assess all-cause and cardiovascular mortality, myocardial infarction, ischemic stroke, and heart failure over a follow-up period of approximately 12.
The study aimed to investigate differences in hypertensive- and cardio-preventive pharmacotherapy depending on if patients with hypertension received lifestyle counseling or not, including the difference between men and women. Data from the Region Stockholm VAL database was used to identify all patients with a hypertension diagnosis and had visited a primary health care center within the past five years. Data included registered diagnoses, pharmacotherapy, and codes for lifestyle counseling.
View Article and Find Full Text PDFBackground: There is a lack of studies on sarcoidosis among immigrants, which is of interest as there may be genetic and environmental characteristics affecting immigrants from certain countries. We aimed to study hazard ratios (HRs) of sarcoidosis in first- and second-generation immigrants, comparing them with native Swedes in the total adult Swedish population.
Methods: We conducted a nationwide study of individuals ≥18 y of age.
Introduction: Care transitions following a stroke call for integrated care approaches to reduce death and disability. The proposed research described in this study protocol aims to evaluate the effectiveness of a person-centred multicomponent care transition support and the process in terms of contextual moderators, implementation aspects and mechanisms of impact.
Methods: A non-randomized controlled trial design will be used.
Introduction: Falls and fall-related injuries in older persons are a major public health problem. Our objective was to study the predictive value of the Short Physical Performance Battery (SPPB) in the cohort of the SCOPE project on falls, injurious falls, and possible difference of prediction between indoors and outdoors falls.
Methods: For this sub-study of the SCOPE project participants reporting no falls at baseline, and survey data on falls at the 12-month and 24-month follow-up were included.
Background: Little is known about risks of hypertensive disorders of pregnancy in both first- and second-generation immigrant women in Europe and other Western countries; such knowledge may help elucidate the influence of genetic versus social factors on such risks. We aimed to study both first- and second-generation immigrant women for the presence of all types of hypertension (preexisting hypertension, gestational hypertension, preeclampsia, and eclampsia) during pregnancy.
Methods And Results: A cohort study was conducted using data derived from the Swedish National Birth Register, the National Patient Register, and the Total Population Register.
Article Synopsis
- The study investigates the impact of prior stress-induced exhaustion disorder (SED) and depression on individuals' well-being by comparing those with and without these conditions in a large cohort from Region Stockholm.
- It finds that individuals with prior SED are more likely to experience stress-related diagnoses and post-viral fatigue, while depression is linked with a wider range of disorders including PTSD and substance use disorders.
- The differing patterns of psychiatric comorbidity between SED and depression indicate distinct underlying mechanisms and clinical outcomes for each condition.
Article Synopsis
- Sarcopenia, heart failure (HF), and chronic kidney disease (CKD) are prevalent issues among older adults, and this study aimed to assess how common sarcopenia is in older adults with HF, considering the role of CKD.
- In a study of 1,420 community-dwelling individuals aged 75 and older, about 15.9% were diagnosed with chronic HF; 11.5% of those with HF and 10.7% without met the criteria for sarcopenia as defined by the EWGSOP2 guidelines.
- Results indicated that lower body mass index (BMI) and poorer physical performance were significant factors linked to sarcopenia, and while HF patients
Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population.
Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC).
Aim: Sarcopenia is associated with several factors and medical conditions among older adults, though previous research has shown limitations and inconsistencies, especially regarding chronic kidney disease (CKD). We investigated the clinical and laboratory variables associated with sarcopenia and severe sarcopenia in older adults, focusing on kidney function measures.
Methods: Data from community-dwelling adults aged ≥75 years participating in the SCOPE multicenter prospective cohort study were assessed cross-sectionally.
Background: Chronic stress and depression are potential risk factors for mild cognitive impairment and dementia, including Alzheimer disease. The aim was to investigate whether any such risk is additive.
Methods: Cohort study including 1 362 548 people (665 997 women, 696 551 men) with records in the Region Stockholm administrative healthcare database (VAL).
C-reactive protein (CRP)/Albumin ratio (CAR) seems to mirror disease severity and prognosis in several acute disorders particularly in elderly patients, which we aimed to study. As method we use a prospective study design; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; = 912, women 50%; mean age 70 years, baseline 2001 and 2004, median follow-up 15.0 years, end of follow-up 2019) and the Uppsala Longitudinal Study of Adult Men (ULSAM, = 924 mean age 71 years, baseline 1991-1995, median follow-up 15.
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- Type 2 diabetes mellitus (DM) in older adults shows different characteristics compared to younger populations, increasing risks of disability and cognitive issues.
- A study analyzed older adults (75+) over two years to assess functional and cognitive impairments in those with and without DM, involving 1611 participants.
- Results showed similar rates of impairment (9.6%) between both groups, with female gender, history of stroke, and greater dependency in daily activities being significant factors for disability in those with DM.