Evaluation of the diagnostic performance of Alpha-1-Antitrypsin in early detection of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) constitutes one of the most frequent cancer types and accounting the vast majority of tumour-related fatalities worldwide. HCC is remain related to a bad prognosis in patients with an advanced disease stage. This study was conducted to evaluate the relationship between A1AT concentration, A1AT gene promoter methylation, and A1AT genotype variation, and HCC risk.