Publications by authors named "Awen Yang"
Clinical Characteristics and Molecular Epidemiology of ST23 in China.
Infect Drug Resist
December 2023
Purpose: In clinical settings, CG23 () is the most virulent clonal group of . Continuous fusions of hypervirulent (Hv) and highly resistant strains have been reported; however, few studies have analysed the molecular epidemiology and clinical characteristics of CG23 strains, especially MDR-sequence type ST23 strains. In this study, we investigated the molecular characteristics of ST23 and analysed the clinical characteristics of ST23 infections in a large teaching hospital of the third class in China.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the genetic characteristics of bacterial strains producing colibactin, particularly looking at differences between strains that are positive or negative for certain virulence factors.
- A total of 2,709 bacterial genomes were analyzed, revealing that -positive strains had more virulence genes and variations in mobile genetic elements compared to -negative strains.
- The findings highlight that -positive strains are associated with higher detection rates in clinical abscess samples, indicating their potential impact on infections.
Malignant mesothelioma (MM) is a rare aggressive tumor, and bone metastasis often occurs in later stages of this disease. This study aimed to establish a nomogram to predict the prognosis of bone metastasis of patients with MM. Data from the Surveillance, Epidemiology, and End Results database were screened and retrieved.
View Article and Find Full Text PDFPurpose: The type VI system (T6SS) has the potential to be a new virulence factor for hypervirulent (hvKp) strains. This study aimed to characterize the molecular and clinical features of T6SS-positive and T6SS-negative isolates that cause abscesses.
Patients And Methods: A total of 169 non-duplicate strains were isolated from patients with abscesses in a tertiary hospital in China from January 2018 to June 2022, and clinical data were collected.
Dissemination of hypervirulent and carbapenem-resistant Klebsiella pneumoniae (CRKP) has been reported worldwide, posing a serious threat to antimicrobial therapy and public health. Outer membrane vesicles (OMVs) act as vectors for the horizontal transfer of virulence and resistance genes. However, K.
View Article and Find Full Text PDFBackground: Fecal carriage of extended-spectrum β-lactamase-producing (ESBL-EC) and carbapenemase-producing (CP-EC) is well reported among hospitalized adults and children. However, there are few studies on the carriage prevalence and ESBL-EC and CP-EC genotypes among healthy children in China.
Patients And Methods: Stool samples were collected from 330 students in 2021 from three randomly selected primary schools in Changsha, China.