Publications by authors named "Awale Isse"
Article Synopsis
- Vaccinations are powerful tools against infectious diseases, but understanding immune responses is crucial due to issues like cross-reactions.
- Researchers studied linear epitopes in the immune response to tetanus toxin using peptide arrays from 19 vaccinated Europeans, identifying a key epitope that binds strongly to antibodies.
- The findings reveal that antibody fingerprints are consistent across individuals and can serve as specific biomarkers to explore cross-reactivity in immune responses to various protein antigens.
Lyme disease is the most common tick-borne infectious disease in Europe and North America. Previous studies discovered the immunogenic role of a surface-exposed lipoprotein (VlsE) of . We employed high density peptide arrays to investigate the antibody response to the VlsE protein in VlsE-positive patients by mapping the protein as overlapping peptides and subsequent in-depth epitope substitution analyses.
View Article and Find Full Text PDFThe antibody species that patrol in a patient's blood are an invaluable part of the immune system. While most of them shield us from life-threatening infections, some of them do harm in autoimmune diseases. If we knew exactly all the antigens that elicited all the antibody species within a group of patients, we could learn which ones correlate with immune protection, are irrelevant, or do harm.
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