Metaplastic breast cancer: Experience with ifosfamide based chemotherapy.

Background: Metaplastic breast cancer (MPBC) is a rare variant of breast cancer and most treatment protocols are based on the guidelines for triple negative breast cancer. However, response to standard anthracycline and taxane based chemotherapy is poor. Published literature on use of ifosfamide based chemotherapy in the first line setting for MPBC is scarce.

Metastatic Ectopic Thymoma of the Neck without Mediastinal Involvement.

Introduction: Thymoma is a rare malignancy with usual location in the antero-superior mediastinum. Occurrence of an extra-mediastinal thymic malignancy in the neck with lung metastasis and without involvement of the mediastinum is an extremely rare condition. Staging systems and treatment guidelines are defined for mediastinal thymomas but not for ectopically located thymomas.

Health-related quality of life among breast cancer patients in India.

Purpose: This study evaluated the health-related quality of life (HRQoL) among breast cancer patients during various phases of treatment and with different treatment modalities, which helps in monitoring treatment outcomes, assessing the well-being of patients, and conducting health technology assessments.

Methods: A total of 534 interviews were conducted among the patients of breast cancer recruited at different stages of disease and with different treatment modalities. HRQoL was determined using EuroQoL five dimensions questionnaire with five levels (EQ-5D-5L), EuroQoL Visual Analogue Scale (EQ VAS), and the EORTC QLQ-BR23 instrument.

Time to Surgery in Spinal Trauma: A Meta-Analysis of the World's Literature Comparing High-Income Countries to Low-Middle Income Countries.

Objective: We conducted a systematic review and meta-analysis to: 1) compare time from traumatic spinal injury (TSI) to operating room (OR) in high-income countries (HICs) versus low-middle-income countries (LMICs), and 2) evaluate hospital length of stay (LOS) in HICs versus LMICs.

Methods: A systematic literature search was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines involving articles of all languages.

Inclusion Criteria: published between 1991 and 2021, spine trauma population, single country/region, and recorded time from injury to OR.

Some Classes of Logarithmic-Type Imputation Techniques for Handling Missing Data.

In this manuscript, three new classes of log-type imputation techniques have been proposed to handle missing data when conducting surveys. The corresponding classes of point estimators have been derived for estimating the population mean. Their properties (Mean Square Errors and bias) have been studied.

An Exponential-Cum-Sine-Type Hybrid Imputation Technique for Missing Data.

In this study, a new exponential-cum-sine-type hybrid imputation technique has been proposed to handle missing data when conducting surveys. The properties of the corresponding point estimator for population mean have been examined in terms of bias and mean square errors. An extensive simulation study using data generated from normal, Poisson, and Gamma distributions has been conducted to evaluate how the proposed estimator performs in comparison to several contemporary estimators.

Impact of COVID-19 on Outcomes for Patients With Cervical Cancer in India.

Purpose: The COVID-19 pandemic has placed unprecedented demands on the health system. This led to delays in the initiation and completion of cancer treatment. We assessed the long-term health consequences because of the delay in diagnosis and treatment for cervical cancer due to COVID-19 in India.

Plaque brachytherapy for choroidal melanoma with vitreous haemorrhage: a therapeutic challenge.

A 47-year-old man presented with profound loss of vision in right eye and relative afferent pupillary defect. On fundus examination, posterior pole details were obscured due to dense vitreous haemorrhage. B-scan ultrasonography was performed that revealed a mushroom-shaped hyperechoic lesion with medium internal reflectivity on A-scan ultrasonography.

Extraosseous Ewing's Sarcoma of the Parapharyngeal Space - A Rare Entity - with Review of Literature.

Introduction: Extraosseous Ewing's sarcoma (EES) of the head and neck region is a rare occurrence, and Ewing's sarcoma of the parapharyngeal space is even rarer. To the best of our knowledge, only three cases of EES of the parapharyngeal space have been reported in the literature.

Case Report: We report a rare case of EES of the parapharyngeal space in an 8-year-old girl.

Polymorphous Low Grade Adenocarcinoma of the Parotid in a Teenager.

Introduction: Polymorphous low grade adenocarcinoma (PLGA) is a rare salivary gland neoplasm with an indolent course. It occurs primarily in the minor salivary glands but can rarely occur in the major salivary glands. It usually occurs in the fifth to seventh decades of life with female preponderance.

Complementary and alternative medicine use among the cancer patients in Northern India.

Background: Cancer has emerged as a major public health problem. People often turn to complementary and alternative medicine (CAM) when they have a long-lasting problem. CAM is a group of diverse medical and healthcare systems, practices, and products that are not generally considered part of conventional medicine.

Apropos of a case of cutaneous metastasis from laryngeal cancer with review of literature.

Cutaneous metastasis from laryngeal carcinoma is a rare occurrence. A 55-year-old male patient with supraglottic cancer was treated with concurrent chemoradiation. Eighteen months later, he presented with ulceroproliferative growth on dorsum of the right hand.

Ovarian granulosa cell tumor: clinical features, treatment, outcome, and prognostic factors.

Background: Granulosa cell tumors are rare neoplasms characterized by long natural history and favorable prognosis.

Aims: The objective of this study was to determine the clinical presentation, treatment, outcome, and prognostic factors for patients of granulosa cell tumors.

Materials And Methods: A retrospective analysis of 26 patients of granulosa cell tumor of ovary from 2002 to 2011 was carried out.

Conventional radiotherapy with concurrent weekly Cisplatin in locally advanced head and neck cancers of squamous cell origin - a single institution experience.

Background: Platinum based concurrent chemo-radiation is the de-facto standard of care in the non-surgical management of locally-advanced head and neck cancer of squamous origin. Three-weekly single agent cisplatin at 100 mg/m2 concurrent with radical radiotherapy has demonstrated consistent improvement in loco-regional control and survival. This improvement is however at the cost of considerable hematologic toxicity and poor overall compliance.

Long term survival in non-small-cell lung carcinoma with synchronous brain metastasis.

Brain metastasis is common in patients with non-small-cell lung carcinoma (NSCLC) and is associated with poor prognosis with a median survival rate below six months, even if treated with palliative radiotherapy and/or chemotherapy. Here, we report a case of NSCLC with synchronous brain metastasis treated with whole brain radiotherapy, systemic chemotherapy and oral gefitinib with survival of 62 months. We found that adequate treatment combining radiotherapy, chemotherapy and targeted therapy in a patient with non-small-cell lung cancer with brain metastasis can improve survival.