Publications by authors named "Avva Saniee"
Protective antibody responses to vaccination or infection depend on affinity maturation, a process by which high-affinity germinal center (GC) B cells are selected on the basis of their ability to bind, gather, and present antigen to T follicular helper (T) cells. Here, we show that human GC B cells have intrinsically higher-affinity thresholds for both B cell antigen receptor (BCR) signaling and antigen gathering as compared with naïve B cells and that these functions are mediated by distinct cellular structures and pathways that ultimately lead to antigen affinity- and T cell-dependent differentiation to plasma cells. GC B cells bound antigen through highly dynamic, actin- and ezrin-rich pod-like structures that concentrated BCRs.
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- The dietary specialist fruit fly has adapted to thrive on the toxic fruit of its host plant, which contains high levels of octanoic acid (OA).
- Previous research using RNA interference (RNAi) indicated that certain genes are crucial for resistance to OA, revealing that multiple regions of the genome influence this trait.
- In this study, RNA-sequencing was used to identify 104 differentially expressed genes in response to OA exposure, highlighting new candidate genes and their roles in cuticle development and immune responses that may contribute to OA resistance.