Development of a computerized morphometry application for assessment of the tumor fraction in colon carcinoma tissue samples.

Determining the fraction of tumor cells in colon carcinoma samples analyzed for KRAS mutation status is important for choosing the proper testing modality and accurately interpreting the results. However, when asked to determine the tumor cell fraction in tissue samples, different pathologists give considerably different estimations, possibly leading to erroneous interpretation of KRAS mutation analysis results and poor treatment choices. To address this issue, we developed a free, easy-to-use computer program that estimates the tumor cell fraction on colon carcinoma slides that are immune-stained with anti-cytokeratin antibody.

Effects of synchronized cardiac assist device on cardiac energetics.

A novel physiological cardiac assist device (PCAD), the LEV RAM assist device, which is synchronized with the failing heart ejection, was developed to improve the failing heart systolic and diastolic functions and cardiac energetics. The PCAD uses a single short cannula, which is inserted into the beating left ventricle (LV) by means of a specially designed device. Blood is ejected from the PCAD into the LV after the opening of the aortic valve and augments the cardiac stroke work.

Gradient field switching as a source for artifacts in MR imaging of metallic stents.

Metallic implants, such as stents, have long been a concern in magnetic resonance imaging (MRI). In addition to safety issues, they are commonly associated with image artifacts. The mechanisms of radiofrequency- (RF) and susceptibility-induced artifacts have been thoroughly investigated.

Augmentation of dilated failing left ventricular stroke work by a physiological cardiac assist device.

A novel physiological cardiac assist device (PCAD), otherwise known as the LEVRAM assist device, which is synchronized with the heartbeat, was developed to assist the left ventricle (LV) in chronic heart failure (CHF). The PCAD utilizes a single cannula, which is inserted in less than 15 s through the apex of the beating LV by means of a specially designed device. Blood is withdrawn from the LV into the PCAD in diastole and is injected back to the LV, through the same cannula, during the systolic ejection phase, thereby augmenting stroke volume (SV) and stroke work (SW).

In vivo extracellular recording of sympathetic ganglion activity in a chronic animal model.

Surgery of the sympathetic system is performed for a variety of indications, hyperhidrosis being a major one. Despite excellent results, sympathectomy for hyperhidrosis bears a number of sequels, some of which may be devastating. Several surgical methods, empirically advocated to alleviate these problems, have only limited success.