Publications by authors named "Avril Adelman"
Article Synopsis
- The study re-evaluated the impact of fresh versus standard storage red blood cell transfusions on mortality and organ dysfunction, finding no significant differences in outcomes.
- A subset of 100 subjects was analyzed for changes in coagulation and immune parameters before and after transfusion, observing mostly no differences between the two RBC groups.
- Although the type of RBC storage did not significantly affect immune or coagulation parameters, notable changes occurred in several specific factors post-transfusion.
To understand how extracellular vesicle (EV) subtypes differentially activate monocytes, a series of studies were performed. We found that plasma-EVs biased monocytes toward an M1 profile. Culturing monocytes with granulocyte-, monocyte-, and endothelial-EVs induced several pro-inflammatory cytokines.
View Article and Find Full Text PDFIntroduction And Hypothesis: The impoverished West African country of Niger has high rates of obstetric fistula. We report a 6-month postoperative follow-up of 384 patients from the Danja Fistula Center and assess factors associated with operative success or failure.
Methods: The medical records of 384 women who had completed a 6-month follow-up after fistula surgery were reviewed.
Unlabelled: Fifteen known type 2 diabetes (T2D) gene variants were assessed for their associations with T2D status in 228 T2D families from the Framingham Heart Study (FHS) Original, Offspring, and Children Cohorts. Bayesian approach was used to test single-single-nucleotide polymorphism (SNP) association followed by logistic regression. Bayesian and logic regression approaches were used to test multiple SNP association searching for the best combinations of variants followed by logistic regression reconfirmation.
View Article and Find Full Text PDFBackground: We report longitudinal changes in the metabolic syndrome (MetS) in 2,458 participants from 480 families in the Family Heart Study. Participants were examined between 1994-96 (FHS-T1) and 2002-03 (FHS-T2), about 7.4 years apart.
View Article and Find Full Text PDFBackground: The present analyses investigated possible pathways for earlier reported associations in the National Heart, Lung, and Blood Institute Family Heart Study between hostility and coronary and carotid end points.
Methods: The cross-sectional design recruited 535 women and 491 men with average familial risk for coronary heart disease and 1950 women and 1667 men with high familial coronary risk from 3 prospective ongoing studies at 4 sites. Recruitment of high-risk participants was based on family risk score.