Deep Learning for Validating and Estimating Resolution of Cryo-Electron Microscopy Density Maps .

Cryo-electron microscopy (cryo-EM) is becoming the imaging method of choice for determining protein structures. Many atomic structures have been resolved based on an exponentially growing number of published three-dimensional (3D) high resolution cryo-EM density maps. However, the resolution value claimed for the reconstructed 3D density map has been the topic of scientific debate for many years.

Therapeutic approaches to the treatment of recurrent respiratory papillomatosis of the aerodigestive tract (a clinical study).

Recurrent respiratory papillomatosis (RRP) is a rare disease, characterized by recurrent proliferation of benign squamous cell papillomas in the larynx as well as in the other parts of the aerodigestive tract. We have compared different treatment options for RRP of the aerodigestive tract including surgical, conservative and combined approaches. A total of 43 patients with papillomatosis that received a combined therapy were followed in the period from 2009 to 2013.

Immunomodulatory effects of BCG in patients with recurrent respiratory papillomatosis.

Background: Recurrent respiratory papillomatosis (RRP) is a rare manifestation of human papilloma virus (HPV) infection with extremely high relapse frequency, poorly understood immunopathogenesis, and lack of efficient treatment. Immunotherapy with Calgevax (BCG) in combination with CO2 surgery significantly improves the outcome of RRP. The present study investigates cellular immunity parameters in RRP patients, and the effects of 20-month Calgevax immunomodulation.

[Oral form of fibrolipoma].

The pleomorphism of the tussies taking part in the formation of oral cavity is basis for the great majority of benign and malignant tumors. They often have similar clinical manifestations macroscopic view. Histological investigations help us for exact diagnosis and adequate treatment.

[Reconstruction of auricular skeleton with maternal ear cartilage in patient with microtia].

The proposed operative technique with maternal auricular cartilage ear-donor) is modification of the method of M. Madzharov et al., for total and partial reconstruction of the auricle.

[Behaviour of patients with inflammatory intracranial complications of otogenic origin].

The authors have the aim to discuss their experience in the field of treatment of otogenic intracranial complications results of inflammatory process. A short reference of the spread of this kind of pathology is made. The up-to-date methods for diagnostics, behaviour, conservative and surgery treatment of these patients are examined.

[Primary melanoma of the nasal and paranasal sinus mucosa].

The authors make short review on the one of most malignant neoplasms in human pathology--its incidence, ethiology, pathogenesis, clinical characteristics, diagnosis, treatment and prognostic features. We present a clinical case from our practice--a melanoma of the nasal cavity and paranasal sinuses--a rare localization. Melanocarcinomas of the mucous membranes of the nasal cavity and paranasal sinuses are almost uniformly fatal.

[Retroperitoneal and mesenteric cysts].

Experience is recorded with the diagnosis and successful surgical treatment of 5 patients with retroperitoneal and mesenterial cysts. According to available data in the literature, one patients with retroperitoneal or mesenteric cyst falls among an average of 34,000-105,000 in-lying patients. Basic symptom on physical examination was a palpable tumor mass in the abdomen.