Publications by authors named "Avitan-Hersh Emily"
Article Synopsis
- Yellow Nail Syndrome (YNS) is a rare condition marked by yellow, malformed nails, swelling due to lymphedema, and chronic lung issues, typically presenting in adulthood, with potential genetic links suggested.
- Researchers conducted genetic sequencing and expression studies on 11 patients (6 with congenital YNS and 5 with sporadic YNS) to investigate its underlying causes.
- Findings revealed biallelic variants in genes related to the Wnt/planar cell polarity pathway in congenital cases, indicating that defects in cellular organization could be key to understanding YNS's development, though the study's small sample size is a limitation.
Article Synopsis
- - Infantile hemangioma (IH) is a common benign tumor in infants that typically resolves on its own, but some cases require treatment with propranolol, which has a high success rate but may lead to rebound growth when stopped.
- - A study of 552 patients found that 12.6% experienced rebound growth after discontinuing propranolol; limb involvement predicted a lower likelihood of rebound growth, while younger age and a specific dose of 2 mg/kg/day improved treatment responses.
- - The research concluded that IHs on limbs displayed reduced rebound growth and better responses to propranolol, highlighting the importance of early treatment initiation and appropriate dosing for better outcomes.
Article Synopsis
- Methacrylate allergy, linked to allergic contact dermatitis, has become more prevalent, leading to the addition of 2-hydroxyethyl methacrylate to the European Baseline Series of allergens.
- A study analyzing 3,828 patients showed that 396 were tested for various methacrylate allergens, with 38.6% testing positive for at least one, primarily 2-hydroxyethyl methacrylate.
- The research indicated that including additional methacrylates, like hydroxypropyl methacrylate and ethylene glycol dimethacrylate, improved detection rates significantly, suggesting that broader testing could identify more cases of allergy.
Background: Leishmaniasis, mainly cutaneous leishmaniasis (CL), is endemic in Israel. In recent years, the diagnosis of leishmaniasis has transitioned to a molecular diagnosis.
Objective: To summarize all cases of leishmaniasis and the identified species seen in Israel based on molecular diagnosis.
Article Synopsis
- The study aimed to understand the causes of pityriasis lichenoides et varioliformis acuta (PLEVA) by analyzing the immune profile and searching for potential viral infections.
- Researchers examined skin samples from patients with PLEVA and those with other skin conditions, focusing on specific types of viruses and immune cells.
- Findings showed a higher presence of certain immune cells in PLEVA patients, suggesting immune damage to the skin, but no viral infections were detected in the samples tested.
Article Synopsis
- Group A Streptococcus (GAS) infections can lead to various skin diseases, and diagnosing such conditions often involves checking for signs of prior GAS infections using ASLO tests.
- A study of 152 patients who underwent ASLO testing revealed that 29% tested positive, with psoriasis and erythema nodosum showing the highest correlation with positive ASLO results.
- The findings suggest that while it's unclear how ASLO applies to all skin diseases, it may be particularly useful in diagnosing psoriasis, as all subtypes of psoriasis presented with positive ASLO results.
Introduction: Early detection may lead to reduced morbidity and mortality from melanoma. This study aims to establish guidelines for selecting patients suitable for digital monitoring of skin lesions.
Methods: A literature review was conducted, followed by consensus among experts appointed by the Israeli Dermatology Association.
Melasma is a commonly occurring pigmented skin condition that can significantly affect one's appearance, described as symmetric hyperpigmentation that presents as irregular brown to gray-brown macules on various facial areas, such as the cheeks, forehead, nasal bridge, and upper lip, along with the mandible and upper arms. Due to its complex pathogenesis and recurrent nature, melasma management is challenging and the outcomes following treatment are not always deemed satisfactory. Solely treating hyperpigmentation may prove ineffective unless paired with regenerative techniques and photoprotection, since one of the main reasons for recurrence is sun exposure.
View Article and Find Full Text PDFmiR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice.
View Article and Find Full Text PDFOnychomycosis is a highly prevalent and persistent nail disorder primarily caused by dermatophytes. The effectiveness of current topical and systemic antifungals is limited by the extent and severity of the infection, patient demographics and health status, hepatic toxicity, drug interactions and low compliance. Laser therapy is a promising modality for safe and cost-effective removal of mycotic nail.
View Article and Find Full Text PDFBackground: Epidermolysis bullosa (EB) features skin and mucosal fragility due to pathogenic variants in genes encoding components of the cutaneous basement membrane. Based on the level of separation within the dermal-epidermal junction, EB is sub-classified into four major types including EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB), and Kindler EB (KEB) with 16 EB-associated genes reported to date.
Methods: We ascertained a cohort of 151 EB patients of various Middle Eastern ethnic backgrounds.
Mycosis fungoides is a rare cutaneous lymphoma in the paediatric population. The aim of this study was to examine the epidemiological, clinical, and histological characteristics, as well as the treatment modalities and response to therapy of paediatric patients with mycosis fungoides. This retrospective cohort study reviewed the records of 37 paediatric patients treated at Rambam Medical Center, Israel, between 2013 and 2021.
View Article and Find Full Text PDFArticle Synopsis
- - Hidradenitis suppurativa (HS) is an inflammatory skin condition typically found in areas with many sweat glands, and this study aims to compare the clinical features of HS in Arab and Jewish patients in the Middle East.
- - The study analyzed data from 164 HS patients, revealing a higher prevalence of the condition in Arab patients (56%) compared to Jewish patients (44%), with common risk factors such as gender, smoking, and obesity affecting severity.
- - Despite significant differences in prevalence and gender among the two groups, both ethnicities displayed similar comorbidities and had a comparable high response rate (83%) to treatment with the drug adalimumab.
Pediatric tinea capitis displays a wide range of prevalence, with significant variability among populations. We retrospectively extracted the medical records of 456 pediatric patients diagnosed with tinea capitis during the years 2010-2021, from the dermatology outpatient clinics in two tertiary medical centers. Three species were isolated in 90% of patients: , , and While presented a six-fold increase in incidence during the years 2019-2021, maintained stable incidence rates.
View Article and Find Full Text PDFBack Grounds And Objective: Infantile hemangiomas (IH) are common benign tumors of infancy. Most IH either involute spontaneously or respond to treatment with systemic Beta- blockers, but unfortunately not in all cases. In poor responses or in cases of contra indications for pharmacological treatment, laser treatment poses a very good solution.
View Article and Find Full Text PDFArginyl-tRNA-protein transferase 1 (ATE1) catalyses N-terminal protein arginylation, a post-translational modification implicated in cell migration, invasion and the cellular stress response. Herein, we report that ATE1 is overexpressed in NRAS-mutant melanomas, while it is downregulated in BRAF-mutant melanomas. ATE1 expression was higher in metastatic tumours, compared with primary tumours.
View Article and Find Full Text PDFObjective: Juvenile psoriatic arthritis (JPsA) is a severe inflammatory arthritis, which is associated with psoriasis in most cases. While there are few validated screening tools for diagnosis of arthritis for adult patients with psoriasis, those screening tools were never evaluated in children. The aims of this study were to evaluate two screening tools among pediatric patients with psoriasis.
View Article and Find Full Text PDFExacerbation of Hailey-Hailey Disease Following SARS-CoV-2 Vaccination.
Acta Derm Venereol
September 2021
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View Article and Find Full Text PDFMutations in FGF23, KL, and GALNT3 have been identified as the cause for the development of hyperphosphatemic familial tumoral calcinosis (HFTC). Patients with HFTC typically present in childhood or adolescence with periarticular soft tissue deposits that eventually progress to disrupt normal joint articulation. Mutations in the GALNT3 gene were shown to account for the hyperphosphatemic state in both HFTC and hyperostosis-hyperphosphatemia syndrome (HHS), the latter characterized by bone involvement.
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