Chloride Transport across Liposomes and Cells by Nontoxic 3-(1-1,2,3-Triazol-1-yl)benzamides.

Synthetic anion transmembrane transporters are adding new aspirations for treating channelopathies by replacing defective ion channels. The availability of such suitable candidates is still infrequent due to the associated toxicity. Here, we report 3-(1-1,2,3-triazol-1-yl)benzamides as transmembrane anion carriers, nontoxic to cells.

Anion Recognition through Multivalent C-H Hydrogen Bonds: Anion-Induced Foldamer Formation and Transport across Phospholipid Membranes.

A series of triazole-cyanostilbene receptors were designed and synthesized. The receptor binds with the anions through various CH···anion hydrogen bonding interactions, where strong binding was observed for SO anions followed by Cl, Br, NO, and I, calculated from the H NMR titration experiment. The NOESY NMR experiment of the receptor confirmed the formation of anion-induced folded conformation.