Publications by authors named "Avinchal Manhas"
Stem Cell Reports
November 2024
Article Synopsis
- In mammals, females have two X chromosomes, but one is silenced to balance dosage between sexes, with recent research showing that the active X chromosome (Xa) is upregulated during mouse embryonic development.
- The study explores whether reactivating the inactive X chromosome (Xi) affects Xa upregulation in various cell types, finding a correlation in some contexts like mouse embryonic epiblasts and stem cells, but not in germ cells.
- Additionally, partial reactivation of Xi in certain cells like mouse extra-embryonic endoderm stem cells and human B cells doesn't lead to loss of Xa upregulation, leading to a new mathematical model for how both X chromosomes are coordinated in transcription.
