Sympathetic ophthalmia in pediatric age group: clinical features and challenges in management in a tertiary center in southern India.

Purpose: To study the clinical features and visual outcome of sympathetic ophthalmia in pediatric patients attending a tertiary care center.

Methods: Retrospective review of patients ≤16 years with sympathetic ophthalmia seen during the period 2001-2011.

Results: During this period, 2511 pediatric patients with open globe injuries and 14 patients with sympathetic ophthalmia were seen.

An ophthalmologist survey-based study of the atypical presentations and current treatment practices of ocular toxoplasmosis in India.

The last two decades have seen a paradigm shift in the understanding of ocular toxoplasmosis. Post-natally acquired infection with its atypical presentations, has emerged as a common form of the disease. We conducted a questionnaire-based survey to investigate the characteristics of atypical presentations and current treatment practices of ocular toxoplasmosis, in India.

Analysis of CFH, TLR4, and APOE polymorphism in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration.

Purpose: To screen polymorphisms in complement factor-H (CFH), toll-like receptor 4 (TLR4), and APOE genes as potential risk factors for age-related macular degeneration (AMD) in Indian patients.

Methods: One hundred patients with AMD and 120 normal control subjects were screened for the polymorphisms by restriction digestion and resequencing. Five intragenic SNPs in CFH were screened to generate haplotype data in cases and controls.